BUB1 Antikörper (Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast)) (AA 281-419)

Details for Product anti-BUB1 Antibody No. ABIN2668285, Anbieter: Anmelden zum Anzeigen
Antigen
  • bub1a
  • bub1l
  • hbub1
  • xbub1
  • BUB1A
  • BUB1L
  • hBUB1
  • AL022991
  • Bub1a
  • C80208
  • D2Xrf87
  • BUB1 mitotic checkpoint serine/threonine kinase
  • BUB1, mitotic checkpoint serine/threonine kinase
  • BUB1
  • bub1
  • Bub1
Epitop
AA 281-419
15
15
13
10
9
9
8
7
4
4
3
3
3
2
2
2
1
1
1
1
Reaktivität
Human, Maus
160
53
35
1
Wirt
Maus
113
47
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser BUB1 Antikörper ist unkonjugiert
4
4
4
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunocytochemistry (ICC), Immunofluorescence (IF)
122
83
51
41
31
19
18
13
12
3
2
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen This Bub1 antibody was raised against a recombinant protein corresponding to amino acids 281-419 of human Bub1.
Klon 14H5
Isotyp IgG
Reinigung Protein G Chromatography
Plasmids, Primers & others Plasmide, Primers & weitere BUB1 products on genomics-online (e.g. as negative or positive controls)
Antigen Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1)
Andere Bezeichnung Bub1 (BUB1 Antibody Abstract)
Hintergrund Bub1 is a serine-threonine protein kinase and an important regulator of cell division. It is essential for the G2/M mitotic spindle assembly/integrity checkpoint as well as critical for chromosome alignment. Bub1 is required for the assembly of a large number of proteins at the kinetochore, including CENP-E, CENP-F, BUB1B, MAD2L1 and PLK1. It plays a role in sister chromatid cohesion and it serves as a substrate for the anaphase-promoting complex. Bub1 mediates cell death in response to chromosome mis-segregation and acts to suppress spontaneous tumorigenesis.
Molekulargewicht 130 kDa
Gen-ID 699
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 μg/μL
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung

Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Lagerung -20 °C
Informationen zur Lagerung Antibodies in solution can be stored at -20 °C for 2 years.
Haltbarkeit 6 months
Produkt verwendet in: Liu, Rattner, Jablonski, Yen: "Mapping the assembly pathways that specify formation of the trilaminar kinetochore plates in human cells." in: The Journal of cell biology, Vol. 175, Issue 1, pp. 41-53, 2006 (PubMed).

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