1810061I13Rik antikoerper, CLEC2 antikoerper, CLEC2B antikoerper, PRO1384 antikoerper, QDED721 antikoerper, Clec-2 antikoerper, Clec2 antikoerper, CLEC1B antikoerper, RGD1563517 antikoerper, CLEC9A antikoerper, C-type lectin domain family 1 member B antikoerper, C-type lectin domain family 1, member b antikoerper, C-type lectin domain family 1, member B antikoerper, CLEC1B antikoerper, Clec1b antikoerper
Substanzklasse
Viral Protein
Hintergrund
CLEC-2, also known as CLEC1B and CLEC1B1, is C-type lectin-like receptor with a single cytoplasmic YXXL sequence known as a hem-immunoreceptor tyrosine-based activation motif (hemITAM). CLEC-2 is highly expressed on resting platelets and megakaryocytes and at a lower levels on several hematopoietic cells including monocytes, macrophages, dendritic cells, and granulocytes. The first ligand that was identified for CLEC-2 was the snake venom toxin rhodocytin, podoplanin has also been identified as an endogenous ligand for CLEC-2. Exposure of platelets to rhodocytin leads tyrosine phosphorylation of the ITAM-like motif and Syk-dependent platelet activation. CLEC-2 also functions as an activation receptor on monoyctes and neutrophils to induce phagocytosis and proinflammatory cytokine production.