CLEC9A Antikörper (PE)

Produktnummer ABIN2662625

Produktdetails anti-CLEC9A Antikörper (PE)

Target: CLEC9A (C-Type Lectin Domain Family 9, Member A (CLEC9A))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CLEC9A Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Aufreinigung: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Klon: 7H11

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.2 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from prolonged exposure to light. Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu CLEC9A

Target: CLEC9A (C-Type Lectin Domain Family 9, Member A (CLEC9A))

Andere Bezeichnung: CD370 (CLEC9A Produkte)

Synonyme: 9830005G06Rik antikoerper, DNGR-1 antikoerper, DNGR1 antikoerper, UNQ9341 antikoerper, RGD1562513 antikoerper, C-type lectin domain family 9, member a antikoerper, C-type lectin domain containing 9A antikoerper, C-type lectin domain family 9, member A antikoerper, Clec9a antikoerper, CLEC9A antikoerper

Hintergrund: CD370 (CLEC9A), also known as DNGR1, is a 264 amino acid (aa) type II transmembrane glycoprotein which belongs to the C-type lectin superfamily. It contains a 208 aa extracellular region with a single carbohydrate recognition domain (CRD) and a cytoplasmic segment (35 aa) bearing an immunoreceptor tyrosine-based activation motif (ITAM). In mice, CLEC9A is strictly expressed on CD8a-positive dendritic cells and plasmacytoid dendritic cells. It recognizes a ubiquitous preformed acid-labile protein associated ligand(s) that is exposed on necrotic cells. CLEC9A ligation is necessary for efficient cross-presentation of dead-cell-associated antigen by recruitment and activation of the tyrosine kinase Syk.