RANKL Antikörper (APC)

Produktnummer ABIN2658141

Produktdetails anti-RANKL Antikörper (APC)

Target: RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RANKL Antikörper ist konjugiert mit APC

Applikation: Western Blotting (WB), ELISA

Aufreinigung: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.

Klon: MIH24

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from prolonged exposure to light. Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu RANKL

Target: RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))

Andere Bezeichnung: CD254 (TNFSF11 Produkte)

Synonyme: CD254 antikoerper, ODF antikoerper, OPGL antikoerper, OPTB2 antikoerper, RANKL antikoerper, TRANCE antikoerper, hRANKL2 antikoerper, sOdf antikoerper, TNFSF11 antikoerper, Ly109l antikoerper, OPG antikoerper, Trance antikoerper, cd254 antikoerper, odf antikoerper, opgl antikoerper, optb2 antikoerper, rankl antikoerper, sodf antikoerper, tnfsf11 antikoerper, trance antikoerper, TNF superfamily member 11 antikoerper, tumor necrosis factor (ligand) superfamily, member 11 antikoerper, TNF receptor superfamily member 11b antikoerper, TNF superfamily member 11 L homeolog antikoerper, TNFSF11 antikoerper, Tnfsf11 antikoerper, TNFRSF11B antikoerper, tnfsf11.L antikoerper

Hintergrund: Human CD254, also known as RANKL, TRANCE, and OPGL, is a type II transmembrane protein in the TNF superfamily that has two forms: a membrane-anchored protein and a secreted protein. Its extracellular domain is related to TRAIL, FasL, and TNF. CD254 is expressed on osteoclasts and activated T cells. It has been implicated in the regulation of the interactions between T cells and dendritic cells. It plays an important role in osteoclast differentiation and bone resorption. CD254 activates JNK and NF-κB and induces the expression of IL-1, IL-6, IL-12, and IL-15 in dendritic cells.

Pathways: NF-kappaB Signalweg