GATA3 Antikörper (Alexa Fluor 488)

Produktnummer ABIN2657081

Produktdetails anti-GATA3 Antikörper (Alexa Fluor 488)

Target: GATA3 (GATA Binding Protein 3 (GATA3))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GATA3 Antikörper ist konjugiert mit Alexa Fluor 488

Applikation: Flow Cytometry (FACS)

Aufreinigung: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions.

Klon: 16E10A23

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from prolonged exposure to light. Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C

Details zu GATA3

Target: GATA3 (GATA Binding Protein 3 (GATA3))

Andere Bezeichnung: GATA3 (GATA3 Produkte)

Synonyme: HDR antikoerper, HDRS antikoerper, Gata-3 antikoerper, jal antikoerper, cb550 antikoerper, gta3 antikoerper, GATA-3 antikoerper, XGATA3 antikoerper, xgata-3 antikoerper, hdr antikoerper, xGATA-3 antikoerper, GATA3 antikoerper, GATA transcription factor 3 antikoerper, T4L20.260 antikoerper, T4L20_260 antikoerper, gata3 antikoerper, ZH-DR antikoerper, zgc:103531 antikoerper, GATA binding protein 3 antikoerper, GATA binding protein 3 S homeolog antikoerper, GATA transcription factor 3 antikoerper, amidase antikoerper, putative amidase antikoerper, GATA-binding protein 3 antikoerper, hematopoietic death receptor antikoerper, GATA3 antikoerper, Gata3 antikoerper, gata3 antikoerper, gata3.S antikoerper, gatA3 antikoerper, hdr antikoerper

Hintergrund: GATA3 functions as a major regulator of T helper 2 (Th2) cell differentiation in immune cells. GATA3 expression is upregulated through IL-4 receptor signaling or the Notch-mediated pathway, which results in production of IL-4, IL-5, and IL-13 cytokines, responsible for preferential differentiation of Th2-cells. GATA3 has been shown to regulate early developmental processes of T cells, such as T cell commitment, positive selection, and post-commitment CD4+ T cell survival. In the mammary gland, GATA3 plays an important role in differentiation and commitment of luminal epithelial cells. In a mouse model, exogenous expression of GATA3 in undifferentiated breast carcinoma cells induces differentiation and suppresses spreading of the tumor cells, suggesting that GATA3 is involved in preventing malignancy of breast cancer. GATA3 has been reported to be essential in the development of a variety of normal tissues. Defect in GATA3 results in hypoparathyroidism, sensorineural deafness, and renal dysplasia (HDR syndrome).

Pathways: Hormone Transport, Regulation of Hormone Metabolic Process, Tube Formation