c-FOS Antikörper (pThr232)
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- Target Alle c-FOS (c-Fos) Antikörper anzeigen
- c-FOS (c-Fos) (c-Fos)
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Bindungsspezifität
- pThr232
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser c-FOS Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Spezifität
- The antibody detects endogenous levels of FOS only when phosphorylated at threonine 232.
- Aufreinigung
- Antibodies were purified by affinity-chromatography using epitope-specific peptide.
- Immunogen
- FOS (phospho Thr232) antibody was raised against a peptide sequence around phosphorylation site of threonine 232 (V-A-T (p)-P-E) derived from Human FOS .
- Isotyp
- IgG
- Top Product
- Discover our top product c-Fos Primärantikörper
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- Applikationshinweise
- Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store antibody at -20°C for up to one year.
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- Target
- c-FOS (c-Fos) (c-Fos)
- Andere Bezeichnung
- FOS (c-Fos Produkte)
- Synonyme
- AP-1 antikoerper, C-FOS antikoerper, p55 antikoerper, c-fos antikoerper, D12Rfj1 antikoerper, cFos antikoerper, cFOS antikoerper, fos antikoerper, Fos proto-oncogene, AP-1 transcription factor subunit antikoerper, FBJ osteosarcoma oncogene antikoerper, proto-oncogene c-Fos-like antikoerper, FOS antikoerper, Fos antikoerper, LOC101078177 antikoerper
- Hintergrund
- Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.
- Molekulargewicht
- 48 kDa
- Gen-ID
- 2353
- NCBI Accession
- NP_005243
- UniProt
- P01100
- Pathways
- S100 Proteine
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