Clusterin Antikörper (C-Term)
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- Target Alle Clusterin (CLU) Antikörper anzeigen
- Clusterin (CLU)
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Bindungsspezifität
- C-Term
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Reaktivität
- Human, Hund
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Wirt
- Ziege
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Klonalität
- Polyklonal
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Konjugat
- Dieser Clusterin Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Spezifität
- This antibody specifically recognises an epitope within the C-terminal (CT) region of human clusterin, otherwise known as Apolipoprotein J, a ubiquitously expressed glycoprotein and member of the clusterin family, implicated in apoptosis (programmed cell death), cell-cell adhesion, DNA repair, membrane recycling, spermatogenesis, and the inhibition of complement-mediated cell lysis. Clusterin is a component of the SC5b-9 complex which plays a role in inhibiting the complement cascade, through the prevention of the binding of a C5b-C7 complex to the membrane of the target cell. Clusterin exists as both a pro-apoptotic form localised to the nucleus, and a pro-survival secreted form, and has been detected at elevated levels in Alzheimer's disease, atherosclerosis, myocardial infarction, and various cancers, including bladder, prostate, and breast tumours.
- Kreuzreaktivität
- Hund
- Produktmerkmale
- Purified IgG
- Aufreinigung
- Purified
- Immunogen
- Synthetic peptide sequence C-EKALQEYRKKHREE from the C-Terminal region of clusterin (NP_001822.2, NP_976084.1).
- Isotyp
- IgG
- Top Product
- Discover our top product CLU Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 0.5 mg/mL
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- Target
- Clusterin (CLU)
- Andere Bezeichnung
- CLUSTERIN (CLU Produkte)
- Synonyme
- LOC100136120 antikoerper, clu antikoerper, MGC53055 antikoerper, zgc:73352 antikoerper, xclu antikoerper, MGC89163 antikoerper, CLU antikoerper, APO-J antikoerper, APOJ antikoerper, CLI antikoerper, CLU1 antikoerper, CLU2 antikoerper, KUB1 antikoerper, NA1/NA2 antikoerper, SGP-2 antikoerper, SGP2 antikoerper, SP-40 antikoerper, TRPM-2 antikoerper, TRPM2 antikoerper, DAG antikoerper, RATTRPM2B antikoerper, SP40 antikoerper, TRPM2B antikoerper, Trpm2 antikoerper, Trpmb antikoerper, AI893575 antikoerper, ApoJ antikoerper, Cli antikoerper, D14Ucla3 antikoerper, Sgp-2 antikoerper, Sgp2 antikoerper, Sugp-2 antikoerper, GP80 antikoerper, gpIII antikoerper, 40 antikoerper, clusterin-1 antikoerper, clusterin L homeolog antikoerper, clusterin antikoerper, Clusterin antikoerper, LOC100136120 antikoerper, clu.L antikoerper, clu antikoerper, CLU antikoerper, clus antikoerper, Clu antikoerper, LOC101113728 antikoerper
- Hintergrund
- Synonyms: APOLIPOPROTEIN J
- Gen-ID
- 1191
- UniProt
- P10909
- Pathways
- Apoptose, Negative Regulation of intrinsic apoptotic Signaling
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