BAFF Antikörper (AA 254-269)

Produktnummer ABIN2470160

Produktdetails anti-BAFF Antikörper

Target: BAFF (TNFSF13B) (Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B))

Bindungsspezifität: AA 254-269

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BAFF Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Aufreinigung: Protein G Column

Immunogen: TNFSF13B antibody was raised against amino acids 254 - 269 of TNFSF13B (Human).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: TNFSF13B antibody can be used in ELISA, Western Blot, and immunohistochemistry starting at 5 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 200 ?L PBS containing 0.05 % BSA, 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: As with all antibodies avoid freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: TNFSF13B antibody can be stored short term 4 °C. For long term storage aliquot and store at -20 °C.

Details zu BAFF

Target: BAFF (TNFSF13B) (Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B))

Andere Bezeichnung: TNFSF13B (TNFSF13B Produkte)

Synonyme: BAFF antikoerper, BLYS antikoerper, CD257 antikoerper, DTL antikoerper, TALL-1 antikoerper, TALL1 antikoerper, THANK antikoerper, TNFSF20 antikoerper, ZTNF4 antikoerper, BAFF-R antikoerper, BAFFR antikoerper, BROMIX antikoerper, CD268 antikoerper, CVID4 antikoerper, prolixin antikoerper, TNFSF13B antikoerper, RGD1561519 antikoerper, RGD1560810 antikoerper, BLyS antikoerper, D8Ertd387e antikoerper, zTNF4 antikoerper, 2010006P15Rik antikoerper, Baffr antikoerper, Bcmd antikoerper, Bcmd-1 antikoerper, Bcmd1 antikoerper, Lvis22 antikoerper, zgc:172115 antikoerper, TNF superfamily member 13b antikoerper, TNF receptor superfamily member 13C antikoerper, tumor necrosis factor (ligand) superfamily, member 13b antikoerper, tumor necrosis factor receptor superfamily, member 13c antikoerper, tumor necrosis factor superfamily member 13b antikoerper, TNFSF13B antikoerper, TNFRSF13C antikoerper, Tnfsf13b antikoerper, Tnfrsf13c antikoerper, tnfsf13b antikoerper

Hintergrund: Simultaneously four different laboratories identified a new member of the tumor necrosis factor (TNF) family. This has been named as TALL-1 , THANK (TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase , BAFF (for B cell activating factor belonging to the TNF family) and Blys (B lymphocyte stimulator). Membrane-bound BAFF is processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein convertases. Secreted BLyS/BAFF/THANK acts as a potent B cell growth factor. Overexpression of BLyS/BAFF in transgenic mice lead to increased numbers of mature B and effector T cells. These mice also develop autoimmune like symptoms, such as, high levels of rheumatoid factors, anti-DNA autoantibodies, etc.. Recently, two receptors for BLyS/BAFF have been identified and termed as BCMA and TACI. Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF (for B cell Activating Factor belonging to the TNF Family), BLyS (for B Lymphocyte Stimulator), TALL-1 (for TNF- and ApoL-related Leukocyte-expressed Ligand), and THANK (for TNF Homologue that Activate Apoptosis, NF-κ,B and c-jun N-terminal Kinase). BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. BAFF and its receptors are essential for B cell development, survival, and humoral immune responses.

Gen-ID: 10673

UniProt: Q9Y275

Pathways: NF-kappaB Signalweg, Production of Molecular Mediator of Immune Response