p107 Antikörper

Produktnummer ABIN2463962

Produktdetails anti-p107 Antikörper

Target: p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser p107 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human RBL1.

Anwendungsinformationen

Applikationshinweise: RBL1 antibody can be used for detection of RBL1 by ELISA at 1:62500. RBL1 antibody can be used for detection of RBL1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store RBL1 antibody at -20 °C.

Details zu p107

Target: p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))

Andere Bezeichnung: RBL1 (RBL1 Produkte)

Synonyme: p107 antikoerper, prb1 antikoerper, fj58e06 antikoerper, wu:fj58e06 antikoerper, CP107 antikoerper, PRB1 antikoerper, AW547426 antikoerper, retinoblastoma-like 1 L homeolog antikoerper, RB transcriptional corepressor like 1 antikoerper, retinoblastoma-like 1 (p107) antikoerper, retinoblastoma-like 1 antikoerper, rbl1.L antikoerper, RBL1 antikoerper, rbl1 antikoerper, Rbl1 antikoerper

Hintergrund: RBL1 is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 115 kDa

Gen-ID: 5933

NCBI Accession: NP_899662

Pathways: Zellzyklus, Mitotic G1-G1/S Phases