H1FOO Antikörper

Produktnummer ABIN2463933

Produktdetails anti-H1FOO Antikörper

Target: H1FOO (H1 Histone Family, Member O, Oocyte-Specific (H1FOO))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser H1FOO Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human H1FOO.

Anwendungsinformationen

Applikationshinweise: H1FOO antibody can be used for detection of H1FOO by ELISA at 1:312500. H1FOO antibody can be used for detection of H1FOO by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store H1FOO antibody at -20 °C.

Details zu H1FOO

Target: H1FOO (H1 Histone Family, Member O, Oocyte-Specific (H1FOO))

Andere Bezeichnung: H1FOO (H1FOO Produkte)

Synonyme: osH1 antikoerper, C86609 antikoerper, H1fo antikoerper, H1oo antikoerper, b4 antikoerper, RGD1566236 antikoerper, H1 histone family member O oocyte specific antikoerper, H1 histone family, member O, oocyte-specific antikoerper, H1 histone family member O oocyte specific S homeolog antikoerper, H1FOO antikoerper, H1foo antikoerper, h1foo.S antikoerper

Hintergrund: H1FOO may play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. H1FOO is essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling.Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The protein encoded is a member of the histone H1 family. The related mouse gene is expressed only in oocytes.

Molekulargewicht: 36 kDa

Gen-ID: 132243

NCBI Accession: NP_722575

UniProt: Q8IZA3