H1FOO Antikörper (N-Term)

Produktnummer ABIN2785287

Produktdetails anti-H1FOO Antikörper

Target: H1FOO (H1 Histone Family, Member O, Oocyte-Specific (H1FOO))

Bindungsspezifität: N-Term

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser H1FOO Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MAPGSVTSDI SPSSTSTAGS SRSPESEKPG PSHGGVPPGG PSHSSLPVGR

Homologie: Human: 100%, Rat: 83%

Produktmerkmale: This is a rabbit polyclonal antibody against H1FOO. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human H1FOO

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 346 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-H1FOO Antikörper (ABIN2785287)

Hongo, Noguchi, Okuyama, Tanaka, Nishino: "Repetitive interactions observed in the crystal structure of a collagen-model peptide, [(Pro-Pro-Gly)9]3." in: Journal of biochemistry, Vol. 138, Issue 2, pp. 135-44, (2005) (PubMed).

Tanaka, Kihara, Hennebold, Eppig, Viveiros, Emery, Carrell, Kirkman, Meczekalski, Zhou, Bondy, Becker, Schultz, Misteli, De La Fuente, King, Adashi: "H1FOO is coupled to the initiation of oocytic growth." in: Biology of reproduction, Vol. 72, Issue 1, pp. 135-42, (2004) (PubMed).

Details zu H1FOO

Target: H1FOO (H1 Histone Family, Member O, Oocyte-Specific (H1FOO))

Andere Bezeichnung: H1FOO (H1FOO Produkte)

Synonyme: osH1 antikoerper, C86609 antikoerper, H1fo antikoerper, H1oo antikoerper, b4 antikoerper, RGD1566236 antikoerper, H1 histone family member O oocyte specific antikoerper, H1 histone family, member O, oocyte-specific antikoerper, H1 histone family member O oocyte specific S homeolog antikoerper, H1FOO antikoerper, H1foo antikoerper, h1foo.S antikoerper

Hintergrund: H1FOO may play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. H1FOO is essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling.Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The protein encoded is a member of the histone H1 family. The related mouse gene is expressed only in oocytes.
Alias Symbols: MGC50807, osH1
Protein Size: 346

Molekulargewicht: 36 kDa

Gen-ID: 132243

NCBI Accession: NM_153833, NP_722575

UniProt: Q8IZA3