GTF2H2 Antikörper

Produktnummer ABIN2463846

Produktdetails anti-GTF2H2 Antikörper

Target: GTF2H2 (General Transcription Factor IIH, Polypeptide 2, 44kDa (GTF2H2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GTF2H2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Aufreinigung: Antibody is purified by protein A chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human GTF2H2.

Anwendungsinformationen

Applikationshinweise: GTF2H2 antibody can be used for detection of GTF2H2 by ELISA at 1:1562500. GTF2H2 antibody can be used for detection of GTF2H2 by western blot at 1.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store GTF2H2 antibody at -20 °C.

Details zu GTF2H2

Target: GTF2H2 (General Transcription Factor IIH, Polypeptide 2, 44kDa (GTF2H2))

Andere Bezeichnung: GTF2H2 (GTF2H2 Produkte)

Synonyme: 44kDa antikoerper, BTF2 p44 antikoerper, BTF2-p44 antikoerper, Btf2p44 antikoerper, p44 antikoerper, BTF2 antikoerper, BTF2P44 antikoerper, T-BTF2P44 antikoerper, TFIIH antikoerper, general transcription factor II H, polypeptide 2 antikoerper, general transcription factor IIH subunit 2 antikoerper, general transcription factor IIH, polypeptide 2, 44kDa antikoerper, Gtf2h2 antikoerper, GTF2H2 antikoerper

Hintergrund: GTF2 is encoded by a gene that is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been described in the literature. It is reported to be different by either two or four base pairs, however, no sequence data is currently available for the centromeric copy of the gene.

Molekulargewicht: 44 kDa

Gen-ID: 2966

NCBI Accession: NP_001506

UniProt: Q13888

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling