GTF2H2 Antikörper (N-Term)
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- Target Alle GTF2H2 Antikörper anzeigen
- GTF2H2 (General Transcription Factor IIH, Polypeptide 2, 44kDa (GTF2H2))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser GTF2H2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Spezifität
- TF2H2 Antibody detects endogenous levels of total TF2H2.
- Homologie
- Pig,Zebrafish,Bovine,Dog,Chicken,Xenopus
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human TF2H2, corresponding to a region within N-terminal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product GTF2H2 Primärantikörper
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- Applikationshinweise
- WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- GTF2H2 (General Transcription Factor IIH, Polypeptide 2, 44kDa (GTF2H2))
- Andere Bezeichnung
- GTF2H2 (GTF2H2 Produkte)
- Synonyme
- 44kDa antikoerper, BTF2 p44 antikoerper, BTF2-p44 antikoerper, Btf2p44 antikoerper, p44 antikoerper, BTF2 antikoerper, BTF2P44 antikoerper, T-BTF2P44 antikoerper, TFIIH antikoerper, general transcription factor II H, polypeptide 2 antikoerper, general transcription factor IIH subunit 2 antikoerper, general transcription factor IIH, polypeptide 2, 44kDa antikoerper, Gtf2h2 antikoerper, GTF2H2 antikoerper
- Hintergrund
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Description: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter.
Gene: GTF2H2
- Molekulargewicht
- 62kDa
- Gen-ID
- 2966
- UniProt
- Q13888
- Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling
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