PILRA Antikörper

Produktnummer ABIN2463032

Produktdetails anti-PILRA Antikörper

Target: PILRA (Paired Immunoglobin-Like Type 2 Receptor alpha (PILRA))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PILRA Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Aufreinigung: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PILRA.

Anwendungsinformationen

Applikationshinweise: PILRA antibody can be used for detection of PILRA by ELISA at 1:1562500. PILRA antibody can be used for detection of PILRA by western blot at 0.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store PILRA antibody at -20 °C.

Details zu PILRA

Target: PILRA (Paired Immunoglobin-Like Type 2 Receptor alpha (PILRA))

Andere Bezeichnung: PILRA (PILRA Produkte)

Synonyme: PILRA antikoerper, FDF03 antikoerper, AV021745 antikoerper, RGD1562847 antikoerper, paired immunoglobin like type 2 receptor alpha antikoerper, paired immunoglobulin-like type 2 receptor alpha antikoerper, paired immunoglobin-like type 2 receptor alpha antikoerper, PILRA antikoerper, LOC489841 antikoerper, Pilra antikoerper

Hintergrund: Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role.Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.

Molekulargewicht: 18 kDa

Gen-ID: 29992

NCBI Accession: NP_840057