UGT1A1 Antikörper

Produktnummer ABIN2462805

Produktdetails anti-UGT1A1 Antikörper

Target: UGT1A1 (UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UGT1A1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Antibody is purified by protein A chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human UGT1A1.

Anwendungsinformationen

Applikationshinweise: UGT1A1 antibody can be used for detection of UGT1A1 by ELISA at 1:1562500. UGT1A1 antibody can be used for detection of UGT1A1 by western blot at 2.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store UGT1A1 antibody at -20 °C.

Details zu UGT1A1

Target: UGT1A1 (UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1))

Andere Bezeichnung: UGT1A1 (UGT1A1 Produkte)

Synonyme: BILIQTL1 antikoerper, GNT1 antikoerper, HUG-BR1 antikoerper, UDPGT antikoerper, UDPGT 1-1 antikoerper, UGT1 antikoerper, UGT1A antikoerper, Gnt1 antikoerper, UGT1A01 antikoerper, Udpgt-1a antikoerper, UgtBr1 antikoerper, Udpgt antikoerper, Ugt1 antikoerper, zgc:123097 antikoerper, UDP glucuronosyltransferase family 1 member A1 antikoerper, UDP glucuronosyltransferase 1 family, polypeptide A1 antikoerper, UDP-glucuronosyltransferase 1-1 antikoerper, UDP-glucuronosyltransferase antikoerper, UDP-glucuronosyltransferase 1-6 antikoerper, UDP glucuronosyltransferase 1 family polypeptide a1 antikoerper, UGT1A1 antikoerper, Ugt1a1 antikoerper, LOC100065342 antikoerper, LOC100125517 antikoerper, LOC100229734 antikoerper, LOC100405984 antikoerper, LOC100511479 antikoerper, ugt1a1 antikoerper

Hintergrund: UGT1A1 is a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids.This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.

Molekulargewicht: 57 kDa

Gen-ID: 54658

NCBI Accession: NP_000454

UniProt: P22309

Pathways: Steroid Hormone Biosynthesis, Regulation of Lipid Metabolism by PPARalpha