NCOR2 Antikörper

Produktnummer ABIN2460475

Produktdetails anti-NCOR2 Antikörper

Target: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NCOR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human NCOR2.

Anwendungsinformationen

Applikationshinweise: NCOR2 antibody can be used for detection of NCOR2 by ELISA at 1:12500. NCOR2 antibody can be used for detection of NCOR2 by western blot at 0.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store NCOR2 antibody at -20 °C.

Details zu NCOR2

Target: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Andere Bezeichnung: NCOR2 (NCOR2 Produkte)

Synonyme: CTG26 antikoerper, N-CoR2 antikoerper, SMAP270 antikoerper, SMRT antikoerper, SMRTE antikoerper, SMRTE-tau antikoerper, TNRC14 antikoerper, TRAC antikoerper, TRAC-1 antikoerper, TRAC1 antikoerper, N-CoR antikoerper, SMRTe antikoerper, NCOR2 antikoerper, gb:be017685 antikoerper, si:bz71m17.2 antikoerper, smrt antikoerper, ctg26 antikoerper, smrte antikoerper, trac1 antikoerper, tnrc14 antikoerper, trac-1 antikoerper, smrte-tau antikoerper, nuclear receptor corepressor 2 antikoerper, nuclear receptor co-repressor 2 antikoerper, NCOR2 antikoerper, Ncor2 antikoerper, ncor2 antikoerper

Hintergrund: NCOR2 forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. NCOR2 mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription.Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.

Molekulargewicht: 275 kDa

Gen-ID: 9612

NCBI Accession: NP_006303

UniProt: Q9Y618

Pathways: Notch Signalweg, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha