DUSP12 Antikörper

Produktnummer ABIN2457984

Produktdetails anti-DUSP12 Antikörper

Target: DUSP12 (Dual Specificity Phosphatase 12 (DUSP12))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DUSP12 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human DUSP12.

Anwendungsinformationen

Applikationshinweise: DUSP12 antibody can be used for detection of DUSP12 by ELISA at 1:1562500. DUSP12 antibody can be used for detection of DUSP12 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store DUSP12 antibody at -20 °C.

Details zu DUSP12

Target: DUSP12 (Dual Specificity Phosphatase 12 (DUSP12))

Andere Bezeichnung: DUSP12 (DUSP12 Produkte)

Synonyme: DUSP12 antikoerper, dusp12 antikoerper, zgc:114069 antikoerper, MGC154526 antikoerper, DUSP1 antikoerper, YVH1 antikoerper, 1190004O14Rik antikoerper, AA027408 antikoerper, AW049275 antikoerper, ESTM36 antikoerper, LMW-DSP4 antikoerper, T-DSP4 antikoerper, VH1 antikoerper, mVH1 antikoerper, GKAP antikoerper, dual specificity phosphatase 12 antikoerper, dual specificity phosphatase 12 L homeolog antikoerper, Dual specificity protein phosphatase 12 antikoerper, dual specificity protein phosphatase 12 antikoerper, DUSP12 antikoerper, dusp12 antikoerper, dusp12.L antikoerper, GL50803_36315 antikoerper, MGYG_01770 antikoerper, Dusp12 antikoerper

Hintergrund: DUSP12 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP12 is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.

Molekulargewicht: 38 kDa

Gen-ID: 11266

NCBI Accession: NP_009171

UniProt: Q9UNI6

Pathways: Regulation of Carbohydrate Metabolic Process