CBLL1 Antikörper

Produktnummer ABIN2192196

Produktdetails anti-CBLL1 Antikörper

Target: CBLL1 (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence-Like 1 (CBLL1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CBLL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Sterilität: 0.2 μm filtered

Anwendungsinformationen

Applikationshinweise: For Western blotting, immunofluorescence and immunohistology dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Haltbarkeit: 12 months

Referenzen für anti-CBLL1 Antikörper (ABIN2192196)

Fujita, Krause, Scheffner, Zechner, Leddy, Behrens, Sommer, Birchmeier: "Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex." in: Nature cell biology, Vol. 4, Issue 3, pp. 222-31, (2002) (PubMed).

Details zu CBLL1

Target: CBLL1 (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence-Like 1 (CBLL1))

Andere Bezeichnung: Hakai (CBLL1 Produkte)

Synonyme: HAKAI antikoerper, RNF188 antikoerper, zgc:55308 antikoerper, CBLL1 antikoerper, AI467391 antikoerper, Hakai antikoerper, c-Cbl-like antikoerper, cbll1 antikoerper, hakai antikoerper, rnf188 antikoerper, Cbl proto-oncogene like 1 antikoerper, Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase S homeolog antikoerper, Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase antikoerper, Casitas B-lineage lymphoma-like 1 antikoerper, Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase L homeolog antikoerper, CBLL1 antikoerper, cbll1.S antikoerper, Cbll1 antikoerper, cbll1 antikoerper, cbll1.L antikoerper

Hintergrund: The polyclonal antibody reacts with human Hakai, a c-Cbl-like protein. Hakai is an E-cadherin binding protein, which has been identified as an E3 ubiquitin-ligase. Hakai contains SH2, RING, zinc-finger and proline-rich domains. Hakai interacts with E-cadherin in a tyrosine phosphorylation-dependent manner, inducing ubiquitination of the E-cadherin complex. Expression of Hakai in epithelial cells disrupts cell-cell contacts and enhances endocytosis of E-cadherin and cell motility. By promoting the endocytosis and dynamic recycling or destruction of E-cadherin complexes, Hakai is able to control epithelial-mesenchymal transitions under physiological and pathological conditions.