C3AR1 Antikörper

Produktnummer ABIN2192050

Produktdetails anti-C3AR1 Antikörper

Target: C3AR1 (Complement Component 3a Receptor 1 (C3AR1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser C3AR1 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Sterilität: 0.2 μm filtered

Klon: 17 (hC3aRZ8)

Anwendungsinformationen

Applikationshinweise: is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Details zu C3AR1

Target: C3AR1 (Complement Component 3a Receptor 1 (C3AR1))

Abstract: C3AR1 Produkte

Synonyme: C3AR antikoerper, C3a-R antikoerper, c3ar1 antikoerper, AZ3B antikoerper, HNFAG09 antikoerper, C3a anaphylatoxin chemotactic receptor antikoerper, complement C3a receptor 1 antikoerper, complement component 3a receptor 1 antikoerper, c3ar1 antikoerper, C3AR1 antikoerper, C3ar1 antikoerper

Hintergrund: The monoclonal antibody 17 reacts with the human receptor for C3a. The monoclonal antibody 17 is in the literature also referred to as clone hC3aRZ8. In the course of complement activation the C3a receptor functions as the cell surface receptor for the anaphylatoxin C3a, the C-terminal 77 amino acid cleavage product of the alpha chain of C3, but not for C3a-desArg. All cellular responses to C3a are specifically mediated by interactions with the membrane bound C3a receptor, a seven transmembrane GTP-binding-protein-coupled receptor that belongs to the rhodopsin supergene family. The 54 kDa C3a receptor is widely distributed in, myeloid cells, peripheral tissues and the central nervous system. Expression of C3aR has been demonstrated on neutrophils, monocytes, eosinophils, astrocytes, neurons and glial cells and is increased in inflammatory conditions. No C3aR expression was detectable on lymphocytes and on tonsillar B cells even after stimulation.

Pathways: Komplementsystem