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Desmoglein 2 Antikörper (DSG2) Primary Antibody

DSG2 Reaktivität: Human IHC (fro), WB Wirt: Maus Monoclonal 6D8 unconjugated
Pubmed (2 Referenzen)
Produktnummer ABIN2191994
$605.98
Zzgl. Versandkosten $45.00
100 μg
Lieferung in 6 bis 8 Werktagen
  • Target Alle Desmoglein 2 (DSG2) Antikörper anzeigen
    Desmoglein 2 (DSG2)
    Reaktivität
    • 100
    • 34
    • 32
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Human
    Wirt
    • 72
    • 29
    Maus
    Klonalität
    • 63
    • 38
    Monoklonal
    Konjugat
    • 48
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Desmoglein 2 Antikörper ist unkonjugiert
    Applikation
    • 78
    • 31
    • 29
    • 28
    • 26
    • 13
    • 13
    • 13
    • 9
    • 8
    • 6
    • 2
    Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
    Kreuzreaktivität (Details)
    Cross reactivity: Human desmoglein-1 : No, Human desmoglein-3 : No
    Sterilität
    0.2 μm filtered
    Klon
    6D8
    Isotyp
    IgG1
  • Applikationshinweise
    For immune fluorescence and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10. Positive A431 Cells control
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
  • Ota, Amagai, Watanabe, Nishikawa: "No involvement of IgG autoantibodies against extracellular domains of desmoglein 2 in paraneoplastic pemphigus or inflammatory bowel diseases." in: Journal of dermatological science, Vol. 32, Issue 2, pp. 137-41, (2003) (PubMed).

    Wahl, Sacco, McGranahan-Sadler, Sauppé, Wheelock, Johnson: "Plakoglobin domains that define its association with the desmosomal cadherins and the classical cadherins: identification of unique and shared domains." in: Journal of cell science, Vol. 109 ( Pt 5), pp. 1143-54, (1996) (PubMed).

  • Target
    Desmoglein 2 (DSG2)
    Andere Bezeichnung
    Desmoglein-2 (DSG2 Produkte)
    Synonyme
    DSG2, dsc, dsga, si:dkeyp-51f12.6, wu:fj23f02, ARVC10, ARVD10, CDHF5, CMD1BB, HDGC, AA408168, D18Ertd293e, desmoglein 2, desmoglein 2, tandem duplicate 1, DSG2, dsg2.1, dsg2, Dsg2
    Hintergrund
    The monoclonal antibody 6D8 recognizes the extracellular domain of human desmoglein-2. Desmogleins and desmocollins are members of the cadherin family of transmembrane proteins that together make up the core of the desmosome, a structure that provides transmembrane strength to tissues undergoing mechanical stress. The desmosomal cadherins, desmogleins and desmocollins, mediate calcium-dependent cell-cell adhesion by forming homotypic and heterotypic interactions with one another. The multiprotein desmosomal complex also includes the cytoplasmic desmosomal plaque proteins plakoglobin, phakophilins, and desmoplakin, which bind to the intracellular domain of the desmogleins and function to anchor the keratin intermediate filament network to site of cell-cell contacts. In human, four desmogleins have been identified (Dsg1-4). Desmogleins are synthesized with a signal peptide that directs them to the endoplasmic reticulum and a proregion that is removed during protein processing. The mature protein includes four highly conserved extracellular domains (EC 1-4) and a fifth membrane proximal, more variable EC domain that is referred to as the "extracellular anchor domain. Desmoglein-2 is expressed on various cells including simple epithelia and myocardium, tumors and and many cell cultures. Desmogleins play critical roles in cell adhesion and skin blistering diseases, as they are the target antigens of autoimmune antibodies and bacterial toxins. Desmosomal dysfunction has been implicated in a number of diseases, including striate palmoplantar keratoderma, skin fragility, and ectodermal dysplasia, and most recently arrhythmic right ventricular cardiomyopathy (ARVC). Aliases Dsg2, Cadherin family member 5, HDGC Immunogen Extracellular EC4 domain
    Pathways
    Cell-Cell Junction Organization
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