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Ficolin 2 Antikörper (Ficolin (Collagen/fibrinogen Domain Containing Lectin) 2 (Hucolin)) (Biotin) Primary Antibody

FCN2 Reaktivität: Human IA, IHC (fro), IP, WB Wirt: Maus Monoclonal GN4 Biotin
Pubmed (2 Referenzen)
Produktnummer ABIN2191966
$534.50
Zzgl. Versandkosten $45.00
50 μg
Lieferung in 6 bis 8 Werktagen
  • Target Alle Ficolin 2 (FCN2) Antikörper anzeigen
    Ficolin 2 (FCN2)
    Reaktivität
    • 28
    • 2
    • 1
    Human
    Wirt
    • 21
    • 8
    Maus
    Klonalität
    • 22
    • 7
    Monoklonal
    Konjugat
    • 14
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Ficolin 2 Antikörper ist konjugiert mit Biotin
    Applikation
    • 15
    • 13
    • 13
    • 8
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    Immunoassay (IA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB)
    Kreuzreaktivität (Details)
    Cross reactivity: Rat : Yes
    Sterilität
    0.2 μm filtered
    Klon
    GN4
    Isotyp
    IgG1
  • Applikationshinweise
    For immunohistochemistry, immunoprecipitation and immuno assays, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
  • Matsushita, Kuraya, Hamasaki, Tsujimura, Shiraki, Fujita: "Activation of the lectin complement pathway by H-ficolin (Hakata antigen)." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 7, pp. 3502-6, (2002) (PubMed).

    Matsushita, Endo, Hamasaki, Fujita: "Activation of the lectin complement pathway by ficolins." in: International immunopharmacology, Vol. 1, Issue 3, pp. 359-63, (2001) (PubMed).

  • Target
    Ficolin 2 (FCN2)
    Andere Bezeichnung
    Ficolin-2 (FCN2 Produkte)
    Synonyme
    EBP-37, FCNL, P35, ficolin-2, Fcn2, FCN1, fcn2, fcn2.S, ficolin 2, ficolin B, ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin), ficolin 2 L homeolog, FCN2, Fcnb, fcn2.L
    Hintergrund
    The monoclonal antibody GN4 recognizes human Ficolin-2, also known as L-ficolin. Ficolins are a family of pattern recognition molecules containing both a collagen-like domain and a fibrinogen-like domain that are capable of activating the complement system, through association with MASPs, on the surface of microorganisms. In human, three Ficolins are known: Ficolin-1 (M-ficolin), Ficolin-2 (L-ficolin), and Ficolin-3 (H-ficolin). Ficolin-1, is mainly expressed by monocytes, granulocytes and lung cells and is present locally in areas of inflammation. Ficolin-2 (also L-ficolin, ficolin L, EBP-37 or hucolin) is produced primarily by the liver. The association between Ficolin-2 and MASPs/sMAP is Ca2+-dependent. MASPs in Ficolin-2- MASP complexes have proteolytic activities for C4, C2 and C3. Ficolin-2 also shows opsonic activity. Aliases Ficolin-2/P35, L-ficolin, ficolin L, EBP-37 or hucolin
    Pathways
    Komplementsystem
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