HPV16 E7 Antikörper (Middle Region)
-
- Target Alle HPV16 E7 (HPV-16 E7) Antikörper anzeigen
- HPV16 E7 (HPV-16 E7) (Human Papilloma Virus 16 E7 (HPV-16 E7))
-
Bindungsspezifität
- Middle Region
-
Reaktivität
- Human Papillomavirus 16 (HPV-16)
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser HPV16 E7 Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
- Spezifität
- This antibody may also detect HPV35-E7
- Kreuzreaktivität
- Human, Virus
- Kreuzreaktivität (Details)
- HPV16
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from middle of HPV16-E7
- Isotyp
- IgG
-
-
- Applikationshinweise
-
WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Haltbarkeit
- 12 months
-
-
Targeting hexokinase 2 inhibition promotes radiosensitization in HPV16 E7-induced cervical cancer and suppresses tumor growth." in: International journal of oncology, Vol. 50, Issue 6, pp. 2011-2023, (2017) (PubMed).
: "HPV16 E6/E7 upregulates HIF-2α and VEGF by inhibiting LKB1 in lung cancer cells." in: Tumour biology, Vol. 39, Issue 7, pp. 1010428317717140, (2017) (PubMed).
: "
-
Targeting hexokinase 2 inhibition promotes radiosensitization in HPV16 E7-induced cervical cancer and suppresses tumor growth." in: International journal of oncology, Vol. 50, Issue 6, pp. 2011-2023, (2017) (PubMed).
-
- Target
- HPV16 E7 (HPV-16 E7) (Human Papilloma Virus 16 E7 (HPV-16 E7))
- Abstract
- HPV-16 E7 Produkte
- Synonyme
- transforming protein E7 antikoerper, E7 antikoerper
- Substanzklasse
- Viral Protein
- Hintergrund
-
Synonyms: Protein E7, E7
Background: Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host inteferon alpha.
- Gen-ID
- 1489079
- UniProt
- P03129
-