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SP1 Antikörper (AA 1-250)

Name: SP1 Antikörper (AA 1-250)
SKU: ABIN1944791
Price: 445.5 EUR
Availability: InStock

SP1 Reaktivität: Human WB, IF, FACS Wirt: Maus Monoclonal 1326CT463-109-176 unconjugated

Western blot analysis of lysates from Hela, Ramos cell line (from left to right), using SP1 Antibody (ABIN1944791 and ABIN2838536). (SP1 Antikörper (AA 1-250))

Flow cytometric analysis of Hela cells using SP1 Antibody (green, Cat(ABIN1944791 and ABIN2838536)) compared to an isotype control of mouse IgG1(blue). (SP1 Antikörper (AA 1-250))

FACS

Fluorescent image of Hela cells stained with SP1 Antibody (ABIN1944791 and ABIN2838536). (SP1 Antikörper (AA 1-250))

3 Abbildungen

(2 Referenzen)

Produktnummer ABIN1944791

Datenblatt (PDF)

Target Alle SP1 Antikörper anzeigen

SP1 (Sp1 Transcription Factor (SP1))
Bindungsspezifität
20

14

12

7

7

7

6

4

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 1-250
Reaktivität
95

64

43

10

7

7

6

5

5

5

4

2

2

2

1
Human
Wirt
97

12

3
Maus
Passende Sekundärantikörper
Klonalität
90

22
Monoklonal
Konjugat
67

6

4

4

4

4

4

4

3

3

2

2

1

1

1

1

1
Dieser SP1 Antikörper ist unkonjugiert
Applikation
90

46

46

38

22

17

13

13

13

8

4

3

3

2

1

1

1
Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Aufreinigung

This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen

This SP1 antibody is generated from a mouse immunized with a recombination protein from the human SP1.

Klon

1326CT463-109-176

Isotyp

IgG1 kappa

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anti-Sp1 Transcription Factor (SP1) (AA 89-199) antibody
SP1 Reaktivität: Human, Maus WB, ELISA, IF Wirt: Maus Monoclonal 4H6 unconjugated

Applikationshinweise

IF: 1:25. WB: 1:1000. FC: 1:25

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Buffer

Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C,-20 °C

Haltbarkeit

6 months
Takahara, Kanazu, Yanagisawa, Akanuma: "Heterogeneous Sp1 mRNAs in human HepG2 cells include a product of homotypic trans-splicing." in: The Journal of biological chemistry, Vol. 275, Issue 48, pp. 38067-72, (2000) (PubMed).

Kadonaga, Carner, Masiarz, Tjian: "Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain." in: Cell, Vol. 51, Issue 6, pp. 1079-90, (1988) (PubMed).
Target

SP1 (Sp1 Transcription Factor (SP1))

Andere Bezeichnung

SP1 (SP1 Produkte)

Synonyme

fc18h09 antikoerper, zgc:85950 antikoerper, wu:fc18h09 antikoerper, SP1 antikoerper, 1110003E12Rik antikoerper, AA450830 antikoerper, AI845540 antikoerper, Sp1-1 antikoerper, sp1 transcription factor antikoerper, Sp1 transcription factor antikoerper, Sp1 transcription factor L homeolog antikoerper, trans-acting transcription factor 1 antikoerper, sp1 antikoerper, SP1 antikoerper, Sp1 antikoerper, sp1.L antikoerper

Hintergrund

Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression.

Molekulargewicht

80693

Gen-ID

6667

UniProt

P08047

Pathways

Regulation of Lipid Metabolism by PPARalpha, Myometrial Relaxation and Contraction