RAPGEF3 Antikörper (N-Term)

Produktnummer ABIN1888161

Produktdetails anti-RAPGEF3 Antikörper

Target: RAPGEF3 (Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAPGEF3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität (Details): At least two isoforms of EPAC1 are known to exist, this antibody will detect both isoforms. EPAC1 antibody is predicted to not cross-react with EPAC2.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: EPAC1 antibody was raised against an 18 amino acid peptide near the amino terminus of human EPAC1.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu RAPGEF3

Target: RAPGEF3 (Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3))

Andere Bezeichnung: EPAC1 (RAPGEF3 Produkte)

Synonyme: RAPGEF3 antikoerper, epac antikoerper, si:dkey-27m20.2 antikoerper, CAMP-GEFI antikoerper, EPAC antikoerper, EPAC1 antikoerper, HSU79275 antikoerper, bcm910 antikoerper, 2310016P22Rik antikoerper, 9330170P05Rik antikoerper, Epac antikoerper, Epac1 antikoerper, Rap guanine nucleotide exchange factor 3 antikoerper, Rap guanine nucleotide exchange factor 3 S homeolog antikoerper, Rap guanine nucleotide exchange factor (GEF) 3 antikoerper, RAPGEF3 antikoerper, rapgef3.S antikoerper, rapgef3 antikoerper, Rapgef3 antikoerper

Hintergrund: EPAC1, also known as Rap guanine nuclear exchange factor 3 and cAMPGEF-I, is widely expressed but most prominently in brain, heart, kidney, pancreas, spleen, ovary, thyroid and spinal cord.EPAC1 is a cAMP-binding protein with intrinsic guanine nuclear exchange factor activity that couples cAMP production to the activation of Rap, a GTPase belonging to the Ras family.This activation of Rap influences numerous cellular processes such as integrin-mediated cell adhesion, vascular endothelial barrier formation, and cardiac myocyte gap junction formation.Recently, EPAC1 has been suggested to also be involved in the cAMP-dependent regulation of ion channel formation, intracellular Ca++ signalling, ion transporter activity, and exocytosis.
Synonyms: Rap guanine nuclear exchange factor 3, RAPGEF3, cAMPGEF-I, bcm910

NCBI Accession: NP_659099

Pathways: cAMP Metabolic Process