FOXO4 Antikörper (N-Term)

Produktnummer ABIN1887931

Produktdetails anti-FOXO4 Antikörper

Target: FOXO4 (Forkhead Box O4 (FOXO4))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FOXO4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 15 amino acid peptide near the amino terminus of human FOXO4.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu FOXO4

Target: FOXO4 (Forkhead Box O4 (FOXO4))

Andere Bezeichnung: FOXO4 (FOXO4 Produkte)

Synonyme: FOXO4 antikoerper, foxo4 antikoerper, AFX antikoerper, AFX1 antikoerper, MLLT7 antikoerper, Afxh antikoerper, Mllt7 antikoerper, afx antikoerper, RGD1561201 antikoerper, forkhead box O4 antikoerper, forkhead box O4 L homeolog antikoerper, FOXO4 antikoerper, foxo4.L antikoerper, Foxo4 antikoerper

Hintergrund: FOXO4 is a ubiquitously expressed protein member of a subfamily of the forkhead homeotic gene family of transcription factors and shuttles between the cytoplasm and nucleus.FOXO transcription factors are key players of cell fate decisions, metabolism, stress resistance, tumor suppression and are regulated by growth factors, oxidative stress or nutrient deprivation.In the absence of PI3K/AKT activation, FOXO4 localizes in the nucleus where it functions as a transcription factor.FOXO4 can also be phosphorylated by JNK following induction of reactive oxygen species (ROS), resulting in transcriptional activation and the induction of a negative feedback mechanism to counteract the ROS.It is through this mechanism that FOXO4 is thought to sensitize cancer cells to doxorubicin-mediated toxicity.
Synonyms: Forkhead box O4, FOXO4A, AFX, AFX1, MLLT7

NCBI Accession: NP_005929

Pathways: Zellzyklus, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Muscle Cell Differentiation