PARL Antikörper (N-Term)

Produktnummer ABIN1887908

Produktdetails anti-PARL Antikörper

Target: PARL (Presenilin Associated, Rhomboid-Like (PARL))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PARL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 15 amino acid peptide from near the amino terminus of human PARL.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu PARL

Target: PARL (Presenilin Associated, Rhomboid-Like (PARL))

Andere Bezeichnung: PARL (PARL Produkte)

Synonyme: PSARL antikoerper, PSARL1 antikoerper, PSENIP2 antikoerper, RHBDS1 antikoerper, D16Ertd607e antikoerper, PRO2207 antikoerper, Psarl antikoerper, parl antikoerper, zgc:112986 antikoerper, presenilin associated rhomboid like antikoerper, presenilin associated, rhomboid-like antikoerper, presenilin associated, rhomboid-like a antikoerper, PARL antikoerper, Parl antikoerper, parla antikoerper

Hintergrund: PARL is a mitochondrial integral membrane protein and a member of the highly conserved rhomboid superfamily of membrane proteins.PARL is required for the control of apoptosis during postnatal growth and is required for the processing of OPA1, a protein that prevents the release of cytochrome C from the mitochondria in response to apoptotic signals.In lymphocytes and neurons, PARL's association with other proteins, such as the Bcl-2 family-related protein Hax1 and Omi can lead to the proteolytic processing of Omi by PARL, preventing the accumulation of Bax, thereby suppressing apoptosis.Variations in this gene have been associated with increased risk for type 2 diabetes.PARL may also play a role in the progression of Alzheimer's disease through its associations with presenilin-1 and -2.Multiple isoforms of PARL are known to exist.
Synonyms: Presenilin-associated rhomboid-like protein, PSARL, PSARL1, PSNENIP2

UniProt: Q9H300

Pathways: Autophagie