FRMPD2 Antikörper (N-Term)

Produktnummer ABIN1887902

Produktdetails anti-FRMPD2 Antikörper

Target: FRMPD2 (FERM and PDZ Domain Containing 2 (FRMPD2))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FRMPD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 15 amino acid peptide from near the amino terminus of human FRMPD2.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu FRMPD2

Target: FRMPD2 (FERM and PDZ Domain Containing 2 (FRMPD2))

Andere Bezeichnung: FRMPD2 (FRMPD2 Produkte)

Synonyme: Frmpd2 antikoerper, Gm1582 antikoerper, ENSMUSG00000071536 antikoerper, FRMPD2 antikoerper, PDZD5C antikoerper, PDZK4 antikoerper, PDZK5C antikoerper, FERM and PDZ domain containing 2 antikoerper, putative protein FRMPD2-like antikoerper, FERM and PDZ domain-containing protein 2 antikoerper, Frmpd2 antikoerper, FRMPD2 antikoerper, LOC100051923 antikoerper, LOC100348282 antikoerper, LOC100548446 antikoerper

Hintergrund: The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain.FRMPD2 also contains an N-terminal KIND domain and three PDZ domains and is structurally similar to the protein tyrosine phosphatase PTP-BL.FRMPD2 is localized in a polarized fashion in epithelial cells at the basolateral membrane and partially co-localizes with the tight-junction marker protein Zonula-occuldens-1.Suppression of FRMPD2 expression via RNAi in Caco-2 cells results in an impairment of tight junction formation, indicating that FRMPD2 plays a major role in tight junction formation.Other experiments indicate that FRMPD2 is a binding partner to several catenin family members and recruitment of FRMPD2 to cell-cell contacts is dependent on E-cadherin-mediated cell-cell adhesion.
Synonyms: FERM and PDZ domain-containing 2, PDZD5C, PDZK5C

NCBI Accession: NP_001018081

Pathways: Cell-Cell Junction Organization