FRMPD2 Antikörper (N-Term)

Produktnummer ABIN6991212

Produktdetails anti-FRMPD2 Antikörper

Target: FRMPD2 (FERM and PDZ Domain Containing 2 (FRMPD2))

Bindungsspezifität: AA 80-130, N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FRMPD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: FRMPD2 Antibody is affinity chromatography purified via peptide column.

Immunogen: FRMPD2 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human FRMPD2. The immunogen is located within amino acids 80 - 130 of FRMPD2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FRMPD2 antibody can be used for detection of FRMPD2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in rat samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: FRMPD2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: FRMPD2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu FRMPD2

Target: FRMPD2 (FERM and PDZ Domain Containing 2 (FRMPD2))

Andere Bezeichnung: FRMPD2 (FRMPD2 Produkte)

Synonyme: Frmpd2 antikoerper, Gm1582 antikoerper, ENSMUSG00000071536 antikoerper, FRMPD2 antikoerper, PDZD5C antikoerper, PDZK4 antikoerper, PDZK5C antikoerper, FERM and PDZ domain containing 2 antikoerper, putative protein FRMPD2-like antikoerper, FERM and PDZ domain-containing protein 2 antikoerper, Frmpd2 antikoerper, FRMPD2 antikoerper, LOC100051923 antikoerper, LOC100348282 antikoerper, LOC100548446 antikoerper

Hintergrund: FRMPD2 Antibody: The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD2 also contains an N-terminal KIND domain and three PDZ domains and is structurally similar to the protein tyrosine phosphatase PTP-BL. FRMPD2 is localized in a polarized fashion in epithelial cells at the basolateral membrane and partially co-localizes with the tight-junction marker protein Zonula-occuldens-1. Suppression of FRMPD2 expression via RNAi in Caco-2 cells results in an impairment of tight junction formation, indicating that FRMPD2 plays a major role in tight junction formation. Other experiments indicate that FRMPD2 is a binding partner to several catenin family members and recruitment of FRMPD2 to cell-cell contacts is dependent on E-cadherin-mediated cell-cell adhesion.

Gen-ID: 143162

NCBI Accession: NP_001018081

UniProt: Q68DX3

Pathways: Cell-Cell Junction Organization