MAPKAP1 Antikörper (Center)

Produktnummer ABIN1887685

Produktdetails anti-MAPKAP1 Antikörper

Target: MAPKAP1 (Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1))

Bindungsspezifität: Center

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAPKAP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide from near the center of human MAPKAP1.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu MAPKAP1

Target: MAPKAP1 (Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1))

Andere Bezeichnung: MAPKAP1 (MAPKAP1 Produkte)

Synonyme: CG10105 antikoerper, Dmel\\CG10105 antikoerper, dSin1 antikoerper, sin1 antikoerper, MAPKAP1 antikoerper, im:7143088 antikoerper, si:ch73-242f23.1 antikoerper, mip1 antikoerper, sin1b antikoerper, sin1g antikoerper, MGC53034 antikoerper, JC310 antikoerper, MIP1 antikoerper, SIN1 antikoerper, SIN1b antikoerper, SIN1g antikoerper, AI591529 antikoerper, D230039K05Rik antikoerper, Sin1 antikoerper, SAPK-interacting protein 1 antikoerper, mitogen-activated protein kinase associated protein 1 antikoerper, mitogen-activated protein kinase associated protein 1 L homeolog antikoerper, Sin1 antikoerper, MAPKAP1 antikoerper, mapkap1 antikoerper, Mapkap1 antikoerper, mapkap1.L antikoerper

Hintergrund: MAPKAP1 was initially identified as the human homolog of S.pombe SIN1.Recent evidence has shown that it identical to Mip1, a protein that interacts with MEKK2, a member of the mitogen-activated protein kinase (MAPK) intracellular signaling network.MAPKAP1 is thought to prevent MEKK2 activation and dimerization by forming a complex with the inactive and non-phosphorylated MEKK2, thereby blocking the JNK1/2, ERK1/2, p38 and ERK5 MAPKs.MAPKAP1 has also been shown to play a role in the TOR signaling process, a pathway that is involved in controlling cell growth and proliferation in response to environmental cues such as nutrients, growth factors and hormones.Experiments showed that MAPKAP1 helped to maintain the TOR/rictor assembly but not the TOR/RAPTOR complex, which allowed specific phosphorylation of Akt, a kinase that is believed to couple the growth factor-PI3K signaling pathway to the nutrient-regulated TOR signaling pathway.Multiple alternatively spliced isoforms of MAPKAP1 have been identified.
Synonyms: Mitogen activated protein kinase associated protein 1, Sin1, stress-activated protein kinase-interacting protein 1, MIP1

NCBI Accession: NP_001006618

Pathways: PI3K-Akt Signalweg, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events