RNASEH2A Antikörper (Center)

Produktnummer ABIN1887662

Produktdetails anti-RNASEH2A Antikörper

Target: RNASEH2A (Ribonuclease H2, Subunit A (RNASEH2A))

Bindungsspezifität: Center

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RNASEH2A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid peptide near the center of human RNAse H2A.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu RNASEH2A

Target: RNASEH2A (Ribonuclease H2, Subunit A (RNASEH2A))

Andere Bezeichnung: RNAse H2A (RNASEH2A Produkte)

Synonyme: 2400006P09Rik antikoerper, RNASEHI antikoerper, RNHIA antikoerper, RNHL antikoerper, zgc:56307 antikoerper, AGS4 antikoerper, JUNB antikoerper, ribonuclease H2 subunit A antikoerper, ribonuclease H2, large subunit antikoerper, ribonuclease H2, subunit A antikoerper, ribonuclease H2 subunit A L homeolog antikoerper, rnaseh2a antikoerper, RNASEH2A antikoerper, Rnaseh2a antikoerper, rnaseh2a.L antikoerper

Hintergrund: Ribonucleases (RNAses) H are enzymes that hydrolyze the RNA strands of RNA/DNA hybrids.The major role of these enzymes is to remove the RNA strand from the RNA/DNA hybrids that form during DNA replication and repair.RNAse H2 is made up of three subunits, all three are required for RNAse activity.Recent evidence has demonstrated that mutations in RNAse H2A or any of the other subunits result in Aicardi-Goutieres syndrome (AGS), a neurological disorder with similar symptoms to viral brain infections including high levels of IFN-alpha in the cerebral spinal fluid.Similar conditions are observed with mutations in TREX1, a single-stranded DNA exonuclease, suggesting that RNAse H2 and TREX1 may have similar roles, and that mutations in any of these genes lead to an accumulation of intracellular nucleic acids, triggering an inflammatory response through activation of the innate immune system.
Synonyms: Rnse H2A, Ribonuclease H2 subunit A, RNAse HI large subunit, Aicadi-Goutieres, syndrome 4 protein, AGS4

UniProt: O75792