BICD2 Antikörper (Center)

Produktnummer ABIN1887500

Produktdetails anti-BICD2 Antikörper

Target: BICD2 (Bicaudal D Homolog 2 (BICD2))

Bindungsspezifität: Center

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BICD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität (Details): This BICD2 antibody will not cross-react with BICD1.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 14 amino acid peptide from near the center of human BICD2.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu BICD2

Target: BICD2 (Bicaudal D Homolog 2 (BICD2))

Andere Bezeichnung: BICD2 (BICD2 Produkte)

Synonyme: SMALED2 antikoerper, bA526D8.1 antikoerper, 0610027D24Rik antikoerper, 1110005D12Rik antikoerper, AA408834 antikoerper, mKIAA0699 antikoerper, MGC84972 antikoerper, BICD2 antikoerper, bicd2 antikoerper, BICD cargo adaptor 2 antikoerper, bicaudal D homolog 2 (Drosophila) antikoerper, BICD cargo adaptor 2 L homeolog antikoerper, zgc:171572 antikoerper, BICD2 antikoerper, Bicd2 antikoerper, bicd2.L antikoerper, bicd2 antikoerper, zgc:171572 antikoerper

Hintergrund: BICD2 is the second human homolog discovered to the Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis.Similar to the highly homologous protein BICD1, BICD2 can bind to dynein-dynactin complex, primarily through the dynamitin subunit of dynactin.The C-terminus of BICD2 targets the protein to the Golgi complex while the N-terminal domain of BICD2 co-immunoprecipitates with cytoplasmic dynein, suggesting BICD2 plays a role in the dynein-dynactin interaction on the surface of membranous organelles.Mice engineered to overexpress the BICD2 amino terminal domain in neurons developed amyotrophic lateral sclerosis (ALS)-like features such as Golgi fragmentation, neurofilament swelling in proximal axons, etc., suggesting that impaired dynein/dynactin function may explain some of the pathological features observed in ALS patients.
Synonyms: Bicaudal D homolog 2

Pathways: Maintenance of Protein Location