Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

BICD2 Antikörper (AA 300-350)

BICD2 Reaktivität: Human, Maus, Ratte WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6990934
  • Target Alle BICD2 Antikörper anzeigen
    BICD2 (Bicaudal D Homolog 2 (BICD2))
    Bindungsspezifität
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    AA 300-350
    Reaktivität
    • 24
    • 4
    • 4
    • 2
    • 2
    Human, Maus, Ratte
    Wirt
    • 22
    • 2
    Kaninchen
    Klonalität
    • 22
    • 2
    Polyklonal
    Konjugat
    • 15
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser BICD2 Antikörper ist unkonjugiert
    Applikation
    • 13
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA
    Spezifität
    This BICD2 antibody will not cross-react with BICD1.
    Aufreinigung
    BICD2 Antibody is affinity chromatography purified via peptide column.
    Immunogen
    BICD2 antibody was raised against a 14 amino acid synthetic peptide from near the center of human BICD2. The immunogen is located within amino acids 300 - 350 of BICD2.
    Isotyp
    IgG
    Top Product
    Discover our top product BICD2 Primärantikörper
  • Applikationshinweise
    BICD2 antibody can be used for detection of BICD2 by Western blot at 1 - 2 μ,g/mL.

    Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    BICD2 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,4 °C
    Informationen zur Lagerung
    BICD2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    BICD2 (Bicaudal D Homolog 2 (BICD2))
    Andere Bezeichnung
    BICD2 (BICD2 Produkte)
    Synonyme
    SMALED2 antikoerper, bA526D8.1 antikoerper, 0610027D24Rik antikoerper, 1110005D12Rik antikoerper, AA408834 antikoerper, mKIAA0699 antikoerper, MGC84972 antikoerper, BICD2 antikoerper, bicd2 antikoerper, BICD cargo adaptor 2 antikoerper, bicaudal D homolog 2 (Drosophila) antikoerper, BICD cargo adaptor 2 L homeolog antikoerper, zgc:171572 antikoerper, BICD2 antikoerper, Bicd2 antikoerper, bicd2.L antikoerper, bicd2 antikoerper, zgc:171572 antikoerper
    Hintergrund
    BICD2 Antibody: BICD2 is the second human homolog discovered to the Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. Similar to the highly homologous protein BICD1, BICD2 can bind to dynein-dynactin complex, primarily through the dynamitin subunit of dynactin. The C-terminus of BICD2 targets the protein to the Golgi complex while the N-terminal domain of BICD2 co-immunoprecipitates with cytoplasmic dynein, suggesting BICD2 plays a role in the dynein-dynactin interaction on the surface of membranous organelles. Mice engineered to overexpress the BICD2 amino terminal domain in neurons developed amyotrophic lateral sclerosis (ALS)-like features such as Golgi fragmentation, neurofilament swelling in proximal axons, etc., suggesting that impaired dynein/dynactin function may explain some of the pathological features observed in ALS patients.
    Molekulargewicht
    Predicted: 94 kDa

    Observed: 100 kDa
    Gen-ID
    23299
    UniProt
    Q8TD16
    Pathways
    Maintenance of Protein Location
Sie sind hier:
Kundenservice