BMF Antikörper (C-Term)

Produktnummer ABIN1887332

Produktdetails anti-BMF Antikörper

Target: BMF (Bcl2 Modifying Factor (BMF))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BMF Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Bmf antibody was raised with a Synthetic peptide corresponding to 14 amino acids near the carboxy terminus of human Bmf.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu BMF

Target: BMF (Bcl2 Modifying Factor (BMF))

Andere Bezeichnung: Bmf (BMF Produkte)

Synonyme: BMF antikoerper, AW260063 antikoerper, AW411872 antikoerper, Bcl2 modifying factor antikoerper, Bcl2 modifying factor L homeolog antikoerper, BCL2 modifying factor antikoerper, BMF antikoerper, bmf.L antikoerper, Bmf antikoerper

Hintergrund: Apoptosis is related to many diseases and development.Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death.Bcl-2 homology 3 (BH3) domain is a potent death domain.BH3-only proteins, including Bad, Bid, Bik, Hrk, Bim, Noxa, and PUMA, form a growing subclass of the Bcl-2 family.A novel BH3-only protein was recently identified in human and mouse and designated Bmf (for Bcl-2-modifing factor).The BH3 domain in Bmf is required both for binding to Bcl-2 proteins and for triggering apoptosis.In healthy cells, Bmf associates with the dynein light chain 2 (DLC2) component of the myosin V motors and is sequestered by the cell's actin cytoskeleton.Disruption of the actin cytoskeleton, either by depolymerization of actin filaments or by detachment of cells from the extracellular matrix, triggers release and activation of Bmf, initiating the downstream apoptotic program.Bmf is constitutively expressed in many tissues.

Molekulargewicht: 25 kDa

NCBI Accession: NP_277038