NUMB Antikörper (C-Term)

Produktnummer ABIN1887202

Produktdetails anti-NUMB Antikörper

Target: NUMB (Numb Homolog (NUMB))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NUMB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: At least four isoforms of NUMB are known to exist, this antibody will detect all of them.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid peptide near the carboxy terminus of human NUMB.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu NUMB

Target: NUMB (Numb Homolog (NUMB))

Andere Bezeichnung: NUMB (NUMB Produkte)

Synonyme: C14orf41 antikoerper, S171 antikoerper, c14_5527 antikoerper, Nb antikoerper, NUMB, endocytic adaptor protein antikoerper, numb homolog (Drosophila) antikoerper, NUMB antikoerper, Numb antikoerper, numb antikoerper

Hintergrund: NUMB, the mammalian homolog to the Drosophila asymmetric cell fate determinant NUMB, is thought to share several features molecular mechanisms in mammalian cells, generating asymmetric cell divisions during neurogenesis in vertebrate development as well as in hematopoietic stem cells.NUMB has been shown to inhibit Notch signaling, and is itself regulated by ubiquitinylation by MDM2.NUMB has also been shown to help activate the tumor suppressor p53, suggesting that loss of NUMB in cancerous cells would not only activate the potential oncogene Notch, but diminish the tumor suppressing effect of p53.
Synonyms: m-NUMB, S171

NCBI Accession: NP_1005743

Pathways: Cell-Cell Junction Organization