SPINK7/ECRG2 Antikörper (C-Term)

Produktnummer ABIN1887135

Produktdetails anti-SPINK7/ECRG2 Antikörper

Target: SPINK7/ECRG2 (SPINK7) (Serine Peptidase Inhibitor, Kazal Type 7 (SPINK7))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPINK7/ECRG2 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Kreuzreaktivität (Details): ECRG2 antibody is predicted to not cross-react with other ECRG family members

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid peptide near the carboxy terminus of human ECRG2.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu SPINK7/ECRG2

Target: SPINK7/ECRG2 (SPINK7) (Serine Peptidase Inhibitor, Kazal Type 7 (SPINK7))

Andere Bezeichnung: ECRG2 (SPINK7 Produkte)

Synonyme: Ecg2 antikoerper, Ecrg2 antikoerper, OM antikoerper, ECG2 antikoerper, ECRG2 antikoerper, EG408198 antikoerper, serine peptidase inhibitor, Kazal type 7 antikoerper, serine peptidase inhibitor, Kazal type 7 (putative) antikoerper, Spink7 antikoerper, SPIK7 antikoerper, SPINK7 antikoerper

Hintergrund: The esophageal cancer-susceptibility gene 2 (ECRG2), also known as SPINK7, is a novel tumor suppressor gene identified from the human esophagus.It interacts directly with metallothionein 2A and urokinase-type plasminogen activator (uPA), and downregulates the activity of uPA, leading to reduced cancer cell migration, invasion and metastasis.ECRG2 forms a complex with uPA and its receptor uPAR, modifying the dynamic association of uPAR with beta1 integrins and disrupting the Src/MAP kinase pathway that normally stimulates cell migration and invasion.ECRG2 may thus represent a novel therapeutic target for cancer.
Synonyms: Esophageal cancer-susceptibility gene 2 protein, ECG2, serine protease inhibitor Kazal-type 7, SPINK7