DFFB Antikörper (AA 203-218)

Produktnummer ABIN1886855

Produktdetails anti-DFFB Antikörper

Target: DFFB (DNA Fragmentation Factor, 40kDa, beta Polypeptide (Caspase-Activated DNase) (DFFB))

Bindungsspezifität: AA 203-218

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DFFB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Peptide corresponding to amino acids 203 to 218 of human DFF40.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu DFFB

Target: DFFB (DNA Fragmentation Factor, 40kDa, beta Polypeptide (Caspase-Activated DNase) (DFFB))

Andere Bezeichnung: DFF40 (DFFB Produkte)

Synonyme: CAD antikoerper, CPAN antikoerper, DFF-40 antikoerper, DFF2 antikoerper, DFF40 antikoerper, LOC100223514 antikoerper, 40kDa antikoerper, 5730477D02Rik antikoerper, Didff antikoerper, Cad antikoerper, carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase antikoerper, DNA fragmentation factor subunit beta antikoerper, DNA fragmentation factor, beta polypeptide (caspase-activated DNase) antikoerper, DNA fragmentation factor, beta subunit antikoerper, CAD antikoerper, DFFB antikoerper, dffb antikoerper, LOC100223514 antikoerper, Dffb antikoerper

Hintergrund: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands.Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases.These death signals finally cause the degradation of chromosomal DNA by activated DNase.A mouse DNase that causes DNA fragmentation was identified recently and designated CAD for caspase activated deoxyribonuclease.The human homologue of mouse CAD was more recently identified by three groups independently and termed CPAN, DFF40, and human CAD, respectively.DFF45/ICAD is the inhibitory protein of DFF40/CAD and forms complex with DFF40/CAD.Upon cleavage of DFF45/ICAD by activated caspase, DFF40/CAD is released and activated and eventually causes the degradation of DNA in the nuclei.Activation of DFF40/CAD, which causes DNA degradation, is the hallmark of apoptotic cell death.
Synonyms: CAD

Molekulargewicht: 40 kDa

NCBI Accession: NP_004393

Pathways: Apoptose, Caspase Kaskade in der Apoptose