HLA-DMA Antikörper (AA 52-255)

Produktnummer ABIN1886528

Produktdetails anti-HLA-DMA Antikörper

Target: HLA-DMA (Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))

Bindungsspezifität: AA 52-255

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HLA-DMA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 52 and 255 of HLA-DMA

Anwendungsinformationen

Applikationshinweise: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.250

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 20 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: Biohazard Informations: This product contains thimerosal which is hazardous.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Details zu HLA-DMA

Target: HLA-DMA (Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))

Andere Bezeichnung: HLA-DMA (HLA-DMA Produkte)

Synonyme: RT1.Ma antikoerper, RT1.DMa antikoerper, HLA-DMA antikoerper, H-2Ma antikoerper, H2-Ma antikoerper, D6S222E antikoerper, DMA antikoerper, HLADM antikoerper, RING6 antikoerper, RT1 class II, locus DMa antikoerper, SLA-DM alpha chain antikoerper, major histocompatibility complex, class II, DM alpha antikoerper, histocompatibility 2, class II, locus DMa antikoerper, RT1-DMa antikoerper, SLA-DMA antikoerper, DLA-DMA antikoerper, H2-DMa antikoerper, HLA-DMA antikoerper

Hintergrund: HLA-DMA belongs to the HLA class II alpha chain paralogues.This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane.It is located in intracellular vesicles.DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site.Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages).The alpha chain is approximately 33-35 kDa and its gene contains 5 exons.Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.[provided by RefSeq]

Molekulargewicht: 29 kDa

Gen-ID: 3108

Pathways: Cancer Immune Checkpoints