RANKL Antikörper (AA 253-317)

Produktnummer ABIN1886269

Produktdetails anti-RANKL Antikörper

Target: RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))

Bindungsspezifität: AA 253-317

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RANKL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Synthetic peptide contain a sequence corresponding to a region within amino acids 253 and 317 of RANKL (CD254)

Anwendungsinformationen

Applikationshinweise: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.250

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: Biohazard Informations: This product contains thimerosal which is hazardous.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Details zu RANKL

Target: RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))

Andere Bezeichnung: RANKL(CD254) (TNFSF11 Produkte)

Synonyme: CD254 antikoerper, ODF antikoerper, OPGL antikoerper, OPTB2 antikoerper, RANKL antikoerper, TRANCE antikoerper, hRANKL2 antikoerper, sOdf antikoerper, TNFSF11 antikoerper, Ly109l antikoerper, OPG antikoerper, Trance antikoerper, cd254 antikoerper, odf antikoerper, opgl antikoerper, optb2 antikoerper, rankl antikoerper, sodf antikoerper, tnfsf11 antikoerper, trance antikoerper, TNF superfamily member 11 antikoerper, tumor necrosis factor (ligand) superfamily, member 11 antikoerper, TNF receptor superfamily member 11b antikoerper, TNF superfamily member 11 L homeolog antikoerper, TNFSF11 antikoerper, Tnfsf11 antikoerper, TNFRSF11B antikoerper, tnfsf11.L antikoerper

Hintergrund: This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation.This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response.T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss.This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis.Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts.The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy.Two alternatively spliced transcript variants have been found.[provided by RefSeq]
Synonyms: ODF, OPGL, sOdf, CD254, OPTB2, RANKL, TRANCE, hRANKL2

Molekulargewicht: 35 kDa

Gen-ID: 8600

NCBI Accession: NP_003692, NM_003701

Pathways: NF-kappaB Signalweg