E-cadherin Antikörper

Produktnummer ABIN1882222

Produktdetails anti-E-cadherin Antikörper

Target: E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser E-cadherin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: Purified His-tagged CDH1 protein was used to produced this monoclonal antibody.

Klon: 813CT11-1-3

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: WB: 1:4000. IHC-P: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-E-cadherin Antikörper (ABIN1882222)

Ren, Qiu, Lü, Ru, Li, Xiang, Yu, Zhang: "TALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells." in: Scientific reports, Vol. 6, pp. 23775, (2017) (PubMed).

Ito, Okamoto, Araki, Kawano, Nakao, Fujiyama, Tomita, Mimori, Saya: "Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of beta-catenin from cell-cell contacts." in: Oncogene, Vol. 18, Issue 50, pp. 7080-90, (2000) (PubMed).

Oda, Kanai, Oyama, Yoshiura, Shimoyama, Birchmeier, Sugimura, Hirohashi: "E-cadherin gene mutations in human gastric carcinoma cell lines." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 5, pp. 1858-62, (1994) (PubMed).

Rimm, Morrow: "Molecular cloning of human E-cadherin suggests a novel subdivision of the cadherin superfamily." in: Biochemical and biophysical research communications, Vol. 200, Issue 3, pp. 1754-61, (1994) (PubMed).

Bussemakers, Giroldi, van Bokhoven, Schalken: "Transcriptional regulation of the human E-cadherin gene in human prostate cancer cell lines: characterization of the human E-cadherin gene promoter." in: Biochemical and biophysical research communications, Vol. 203, Issue 2, pp. 1284-90, (1994) (PubMed).

Bussemakers, van Bokhoven, Mees, Kemler, Schalken: "Molecular cloning and characterization of the human E-cadherin cDNA." in: Molecular biology reports, Vol. 17, Issue 2, pp. 123-8, (1993) (PubMed).

Details zu E-cadherin

Target: E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))

Andere Bezeichnung: CDH1 (CDH1 Produkte)

Synonyme: Arc-1 antikoerper, CD324 antikoerper, CDHE antikoerper, ECAD antikoerper, LCAM antikoerper, UVO antikoerper, E-cadherin antikoerper, cdh1 antikoerper, si:dz180o5.2 antikoerper, uvo antikoerper, lcam antikoerper, E-Cad antikoerper, XBcad antikoerper, l-cam antikoerper, xcdh1 antikoerper, cdhc-A antikoerper, xb-cad antikoerper, XTCAD-1 antikoerper, c-cadherin antikoerper, cadherin-1 antikoerper, uvomorulin antikoerper, XB-cadherin antikoerper, arc-1 antikoerper, cd324 antikoerper, cdhe antikoerper, ecad antikoerper, AA960649 antikoerper, E-cad antikoerper, Ecad antikoerper, L-CAM antikoerper, Um antikoerper, cadherin 1 antikoerper, si:busm1-180o5.2 antikoerper, cadherin 1, type 1, E-cadherin (epithelial) antikoerper, cadherin 1, type 1 S homeolog antikoerper, CDH1 antikoerper, si:busm1-180o5.2 antikoerper, cdh1 antikoerper, Cdh1 antikoerper, cdh1.S antikoerper

Hintergrund: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells, cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.

Molekulargewicht: 97456

NCBI Accession: NP_004351

UniProt: P12830

Pathways: WNT Signalweg, Sensory Perception of Sound, Cell-Cell Junction Organization, Tube Formation