E-cadherin Antikörper
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- Target Alle E-cadherin (CDH1) Antikörper anzeigen
- E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
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Reaktivität
- Human, Maus
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser E-cadherin Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Aufreinigung
- This antibody is purified through a protein G column, followed by dialysis against PBS.
- Immunogen
- Purified His-tagged CDH1 protein was used to produced this monoclonal antibody.
- Klon
- 813CT11-1-3
- Isotyp
- IgG1 kappa
- Top Product
- Discover our top product CDH1 Primärantikörper
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- Applikationshinweise
- WB: 1:4000. IHC-P: 1:25
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Haltbarkeit
- 6 months
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TALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells." in: Scientific reports, Vol. 6, pp. 23775, (2017) (PubMed).
: "Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of beta-catenin from cell-cell contacts." in: Oncogene, Vol. 18, Issue 50, pp. 7080-90, (2000) (PubMed).
: "E-cadherin gene mutations in human gastric carcinoma cell lines." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 5, pp. 1858-62, (1994) (PubMed).
: "Molecular cloning of human E-cadherin suggests a novel subdivision of the cadherin superfamily." in: Biochemical and biophysical research communications, Vol. 200, Issue 3, pp. 1754-61, (1994) (PubMed).
: "Transcriptional regulation of the human E-cadherin gene in human prostate cancer cell lines: characterization of the human E-cadherin gene promoter." in: Biochemical and biophysical research communications, Vol. 203, Issue 2, pp. 1284-90, (1994) (PubMed).
: "Molecular cloning and characterization of the human E-cadherin cDNA." in: Molecular biology reports, Vol. 17, Issue 2, pp. 123-8, (1993) (PubMed).
: "
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TALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells." in: Scientific reports, Vol. 6, pp. 23775, (2017) (PubMed).
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- Target
- E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
- Andere Bezeichnung
- CDH1 (CDH1 Produkte)
- Synonyme
- Arc-1 antikoerper, CD324 antikoerper, CDHE antikoerper, ECAD antikoerper, LCAM antikoerper, UVO antikoerper, E-cadherin antikoerper, cdh1 antikoerper, si:dz180o5.2 antikoerper, uvo antikoerper, lcam antikoerper, E-Cad antikoerper, XBcad antikoerper, l-cam antikoerper, xcdh1 antikoerper, cdhc-A antikoerper, xb-cad antikoerper, XTCAD-1 antikoerper, c-cadherin antikoerper, cadherin-1 antikoerper, uvomorulin antikoerper, XB-cadherin antikoerper, arc-1 antikoerper, cd324 antikoerper, cdhe antikoerper, ecad antikoerper, AA960649 antikoerper, E-cad antikoerper, Ecad antikoerper, L-CAM antikoerper, Um antikoerper, cadherin 1 antikoerper, si:busm1-180o5.2 antikoerper, cadherin 1, type 1, E-cadherin (epithelial) antikoerper, cadherin 1, type 1 S homeolog antikoerper, CDH1 antikoerper, si:busm1-180o5.2 antikoerper, cdh1 antikoerper, Cdh1 antikoerper, cdh1.S antikoerper
- Hintergrund
- Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells, cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
- Molekulargewicht
- 97456
- NCBI Accession
- NP_004351
- UniProt
- P12830
- Pathways
- WNT Signalweg, Sensory Perception of Sound, Cell-Cell Junction Organization, Tube Formation
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