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MEK1 Antikörper (N-Term)

Dieses Anti-MEK1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MEK1 in WB und IHC (p). Geeignet für Human und Maus. Dieses Primary Antibody wurde in 5+ Publikationen zitiert.
Produktnummer ABIN1882101

Kurzübersicht für MEK1 Antikörper (N-Term) (ABIN1882101)

Target

Alle MEK1 (MAP2K1) Antikörper anzeigen
MEK1 (MAP2K1) (Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))

Reaktivität

  • 346
  • 187
  • 181
  • 35
  • 29
  • 19
  • 13
  • 12
  • 12
  • 8
  • 7
  • 5
  • 5
  • 4
  • 2
  • 1
  • 1
  • 1
  • 1
Human, Maus

Wirt

  • 312
  • 32
  • 3
  • 2
  • 2
Kaninchen

Klonalität

  • 271
  • 80
Polyklonal

Konjugat

  • 182
  • 19
  • 14
  • 12
  • 11
  • 10
  • 8
  • 8
  • 8
  • 8
  • 8
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 4
  • 2
  • 2
Dieser MEK1 Antikörper ist unkonjugiert

Applikation

  • 221
  • 114
  • 89
  • 68
  • 66
  • 46
  • 34
  • 26
  • 24
  • 18
  • 15
  • 9
  • 8
  • 7
  • 4
  • 3
  • 3
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon

RB3593
  • Bindungsspezifität

    • 39
    • 28
    • 25
    • 22
    • 21
    • 20
    • 18
    • 16
    • 15
    • 14
    • 10
    • 10
    • 8
    • 8
    • 8
    • 8
    • 7
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-30, N-Term

    Homologie

    Rb, Rat

    Aufreinigung

    This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

    Immunogen

    This MEK1 (MAP2K1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MEK1 (MAP2K1).

    Isotyp

    Ig Fraction
  • Applikationshinweise

    WB: 1:1000. IHC-P: 1:50~100

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Haltbarkeit

    6 months
  • Zheng, Fiumara, Li, Georgakis, Snell, Younes, Vauthey, Carbone, Younes: "MEK/ERK pathway is aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival." in: Blood, Vol. 102, Issue 3, pp. 1019-27, (2003) (PubMed).

    Li, Junttila, Han, Kähäri, Westermarck: "p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2." in: Cancer research, Vol. 63, Issue 13, pp. 3473-7, (2003) (PubMed).

    Zhu, Sun, Lee, Siedlak, Perry, Smith: "Distribution, levels, and activation of MEK1 in Alzheimer's disease." in: Journal of neurochemistry, Vol. 86, Issue 1, pp. 136-42, (2003) (PubMed).

    Fringer, Grinnell: "Fibroblast quiescence in floating collagen matrices: decrease in serum activation of MEK and Raf but not Ras." in: The Journal of biological chemistry, Vol. 278, Issue 23, pp. 20612-7, (2003) (PubMed).

    Witowsky, Johnson: "Ubiquitylation of MEKK1 inhibits its phosphorylation of MKK1 and MKK4 and activation of the ERK1/2 and JNK pathways." in: The Journal of biological chemistry, Vol. 278, Issue 3, pp. 1403-6, (2003) (PubMed).

  • Target

    MEK1 (MAP2K1) (Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))

    Andere Bezeichnung

    MEK1 (MAP2K1)

    Hintergrund

    MAP2K1 is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.

    Molekulargewicht

    43439

    NCBI Accession

    NP_002746

    UniProt

    Q02750

    Pathways

    MAPK Signalweg, RTK Signalweg, Interferon-gamma Pathway, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades, Autophagie, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling
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