MEK1 Antikörper (N-Term)

Produktnummer ABIN1882101

Dieses Anti-MEK1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MEK1 in WB und IHC (p). Geeignet für Human und Maus. Dieses Primary Antibody wurde in 5+ Publikationen zitiert.

Kurzübersicht für MEK1 Antikörper (N-Term) (ABIN1882101)

Target: MEK1 (MAP2K1) (Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MEK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB3593

Produktdetails anti-MEK1 Antikörper

Bindungsspezifität: AA 1-30, N-Term

Homologie: Rb, Rat

Aufreinigung: This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Immunogen: This MEK1 (MAP2K1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MEK1 (MAP2K1).

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-MEK1 Antikörper (ABIN1882101)

Zheng, Fiumara, Li, Georgakis, Snell, Younes, Vauthey, Carbone, Younes: "MEK/ERK pathway is aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival." in: Blood, Vol. 102, Issue 3, pp. 1019-27, (2003) (PubMed).

Li, Junttila, Han, Kähäri, Westermarck: "p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2." in: Cancer research, Vol. 63, Issue 13, pp. 3473-7, (2003) (PubMed).

Zhu, Sun, Lee, Siedlak, Perry, Smith: "Distribution, levels, and activation of MEK1 in Alzheimer's disease." in: Journal of neurochemistry, Vol. 86, Issue 1, pp. 136-42, (2003) (PubMed).

Fringer, Grinnell: "Fibroblast quiescence in floating collagen matrices: decrease in serum activation of MEK and Raf but not Ras." in: The Journal of biological chemistry, Vol. 278, Issue 23, pp. 20612-7, (2003) (PubMed).

Witowsky, Johnson: "Ubiquitylation of MEKK1 inhibits its phosphorylation of MKK1 and MKK4 and activation of the ERK1/2 and JNK pathways." in: The Journal of biological chemistry, Vol. 278, Issue 3, pp. 1403-6, (2003) (PubMed).

Details zu MEK1

Target: MEK1 (MAP2K1) (Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))

Andere Bezeichnung: MEK1 (MAP2K1)

Hintergrund: MAP2K1 is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.

Molekulargewicht: 43439

NCBI Accession: NP_002746

UniProt: Q02750

Pathways: MAPK Signalweg, RTK Signalweg, Interferon-gamma Pathway, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades, Autophagie, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling