C-JUN Antikörper (AA 41-70)

Produktnummer ABIN1881470

Der Kaninchen Polyklonal Anti-C-JUN-Antikörper wurde für WB validiert. Er ist geeignet, C-JUN in Proben von Human zu detektieren. Es sind 3+ Publikationen verfügbar.

Kurzübersicht für C-JUN Antikörper (AA 41-70) (ABIN1881470)

Target: C-JUN (JUN) (Jun Proto-Oncogene (JUN))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C-JUN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB11002

Produktdetails anti-C-JUN Antikörper

Bindungsspezifität: AA 41-70

Homologie: B, M, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This JUN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-70 amino acids from human JUN.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-C-JUN Antikörper (ABIN1881470)

Madhunapantula, Robertson: "Is B-Raf a good therapeutic target for melanoma and other malignancies?" in: Cancer research, Vol. 68, Issue 1, pp. 5-8, (2008) (PubMed).

Fujita, Ito, Mizutani, Minoguchi, Yamamichi, Sakurai, Iba: "miR-21 Gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism." in: Journal of molecular biology, Vol. 378, Issue 3, pp. 492-504, (2008) (PubMed).

Gan, Wang, Xi, Wu, Li, Li: "Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction." in: The Journal of cell biology, Vol. 180, Issue 6, pp. 1087-100, (2008) (PubMed).

Details zu C-JUN

Target: C-JUN (JUN) (Jun Proto-Oncogene (JUN))

Andere Bezeichnung: JUN

Hintergrund: JUN interacts directly with specific target DNA sequences to regulate gene expression. Jun recognizes the AP-1 consensus sequence TGACTCA, a response element that confers sensitivity to one of the tumor-promoting Phorbol esters, 12-O-tetradecanoyl-phorbol-13-acetate (see also: TRE, TPA response element). Jun itself forms homodimers or heterodimers with junD and junB and also interacts with the oncogene product fos, forming jun-fos heterodimers.

Molekulargewicht: 35676

NCBI Accession: NP_002219

UniProt: P05412

Pathways: MAPK Signalweg, RTK Signalweg, WNT Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Skeletal Muscle Fiber Development, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Autophagie, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling, S100 Proteine