EIF3L Antikörper (N-Term)

Produktnummer ABIN1881291

Produktdetails anti-EIF3L Antikörper

Target: EIF3L (Eukaryotic Translation Initiation Factor 3, Subunit L (EIF3L))

Bindungsspezifität: AA 12-40, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EIF3L Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: B, C, M, X

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This EIF3L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-40 amino acids from the N-terminal region of human EIF3L.

Klon: RB41025

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-EIF3L Antikörper (ABIN1881291)

Zhou, Sandercock, Fraser, Ridlova, Stephens, Schenauer, Yokoi-Fong, Barsky, Leary, Hershey, Doudna, Robinson: "Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 47, pp. 18139-44, (2008) (PubMed).

Masutani, Sonenberg, Yokoyama, Imataka: "Reconstitution reveals the functional core of mammalian eIF3." in: The EMBO journal, Vol. 26, Issue 14, pp. 3373-83, (2007) (PubMed).

Damoc, Fraser, Zhou, Videler, Mayeur, Hershey, Doudna, Robinson, Leary: "Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 7, pp. 1135-46, (2007) (PubMed).

Details zu EIF3L

Target: EIF3L (Eukaryotic Translation Initiation Factor 3, Subunit L (EIF3L))

Andere Bezeichnung: EIF3L (EIF3L Produkte)

Synonyme: wu:fb66c05 antikoerper, zgc:64147 antikoerper, EIF3EIP antikoerper, EIF3S11 antikoerper, EIF3S6IP antikoerper, HSPC021 antikoerper, HSPC025 antikoerper, MSTP005 antikoerper, 0610011H21Rik antikoerper, D15N1e antikoerper, Eif3eip antikoerper, Eif3ip antikoerper, Eif3s6ip antikoerper, HSP-66Y antikoerper, PAF67 antikoerper, eif3eip antikoerper, eif3s6ip antikoerper, eukaryotic translation initiation factor 3, subunit 6 interacting protein antikoerper, eukaryotic translation initiation factor 3 subunit L antikoerper, eukaryotic translation initiation factor 3, subunit L antikoerper, eukaryotic translation initiation factor 3 subunit L L homeolog antikoerper, eif3s6ip antikoerper, EIF3L antikoerper, Eif3l antikoerper, eif3l.L antikoerper

Hintergrund: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.

Molekulargewicht: 66727

NCBI Accession: NP_001229852, NP_057175

UniProt: Q9Y262

Pathways: Ribonucleoprotein Complex Subunit Organization