PPM1A Antikörper (AA 202-382)

Produktnummer ABIN1845590

Produktdetails anti-PPM1A Antikörper

Target: PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))

Bindungsspezifität: AA 202-382

Reaktivität: Human, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PPM1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human PPM1A (AA: 202-382) expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: PBS with 0.05 % sodium azide and 0.5 % protein stabilizer.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.

Details zu PPM1A

Target: PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))

Andere Bezeichnung: PPM1A (PPM1A Produkte)

Synonyme: PP2C-ALPHA antikoerper, PP2CA antikoerper, PP2Calpha antikoerper, pp2ca1 antikoerper, ppp1r13b antikoerper, si:ch211-253p18.1 antikoerper, wu:fd42g12 antikoerper, zgc:153820 antikoerper, 2310003C21Rik antikoerper, 2900017D14Rik antikoerper, AI427932 antikoerper, AU017636 antikoerper, MMPa-2 antikoerper, MPPa-1 antikoerper, Pp2c1 antikoerper, pp2c-alpha antikoerper, pp2ca antikoerper, pp2calpha antikoerper, pp2ca2 antikoerper, protein phosphatase, Mg2+/Mn2+ dependent 1A antikoerper, protein phosphatase, Mg2+/Mn2+ dependent, 1Ab antikoerper, protein phosphatase 1A, magnesium dependent, alpha isoform antikoerper, protein phosphatase, Mg2+/Mn2+ dependent, 1A antikoerper, protein phosphatase, Mg2+/Mn2+ dependent 1A L homeolog antikoerper, protein phosphatase, Mg2+/Mn2+ dependent, 1Aa antikoerper, PPM1A antikoerper, ppm1ab antikoerper, Ppm1a antikoerper, ppm1a.L antikoerper, ppm1aa antikoerper

Hintergrund: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Molekulargewicht: 42.4 kDa

Gen-ID: 5494

UniProt: P35813