PPM1A Antikörper (AA 202-382)

Produktnummer ABIN969556

Dieser Maus Monoklonal Antikörper detektiert spezifisch PPM1A in WB, ELISA und FACS. Es zeigt Reaktivität gegenüber Proben von Human und Affe. Es wurde in 2+ Publikationen zitiert.

Kurzübersicht für PPM1A Antikörper (AA 202-382) (ABIN969556)

Target: PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))

Reaktivität: Human, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PPM1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Klon: 7F12H6

Produktdetails anti-PPM1A Antikörper

Bindungsspezifität: AA 202-382

Verwendungszweck: PPM1A Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human PPM1A (AA: 202-382) expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-PPM1A Antikörper (ABIN969556)

Malki, Uher, Paya-Cano, Binder, Rietschel, Zobel, Mors, Hauser, Henigsberg, Jerman, Souery, Placentino, Ng, Cohen-Woods, Sluyter, Farmer, Aitchison, Craig, Lewis, McGuffin, Schalkwyk: "Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants." in: Biological psychiatry, Vol. 69, Issue 4, pp. 360-5, (2011) (PubMed).

Sun, Yu, Dotti, Shen, Tan, Savoldo, Pass, Chu, Zhang, Lu, Fu, Lin, Yang: "PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation." in: Cellular signalling, Vol. 21, Issue 1, pp. 95-102, (2008) (PubMed).

Details zu PPM1A

Target: PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))

Andere Bezeichnung: PPM1A

Hintergrund: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Molekulargewicht: 42.4 kDa

Gen-ID: 5494

UniProt: P20265