RCHY1 Antikörper

Produktnummer ABIN1724723

Produktdetails anti-RCHY1 Antikörper

Target: RCHY1 (Ring Finger and CHY Zinc Finger Domain Containing 1, E3 Ubiquitin Protein Ligase (RCHY1))

Reaktivität: Human, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RCHY1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Aufreinigung: purified

Immunogen: Purified recombinant fragment of human Pirh2 expressed in E. coli.

Klon: 1H10

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: 4°C, -20°C for long term storage

Referenzen für anti-RCHY1 Antikörper (ABIN1724723)

Duan, Gao, Wu, Zhang, Otterson, Villalona-Calero: "Differential response between the p53 ubiquitin-protein ligases Pirh2 and MdM2 following DNA damage in human cancer cells." in: Experimental cell research, Vol. 312, Issue 17, pp. 3370-8, (2006) (PubMed).

Duan, Gao, Druhan, Zhu, Morrison, Otterson, Villalona-Calero: "Expression of Pirh2, a newly identified ubiquitin protein ligase, in lung cancer." in: Journal of the National Cancer Institute, Vol. 96, Issue 22, pp. 1718-21, (2004) (PubMed).

Details zu RCHY1

Target: RCHY1 (Ring Finger and CHY Zinc Finger Domain Containing 1, E3 Ubiquitin Protein Ligase (RCHY1))

Andere Bezeichnung: Pirh2 (RCHY1 Produkte)

Synonyme: ARNIP antikoerper, CHIMP antikoerper, PIRH2 antikoerper, PRO1996 antikoerper, RNF199 antikoerper, ZNF363 antikoerper, Pirh2 antikoerper, Zfp363 antikoerper, Znf363 antikoerper, wu:fb37e07 antikoerper, zgc:101128 antikoerper, RCHY1 antikoerper, arnip antikoerper, chimp antikoerper, pirh2 antikoerper, harnip antikoerper, rnf199 antikoerper, znf363 antikoerper, pro1996 antikoerper, ring finger and CHY zinc finger domain containing 1 antikoerper, ring finger and CHY zinc finger domain containing 1 L homeolog antikoerper, RCHY1 antikoerper, Rchy1 antikoerper, rchy1 antikoerper, rchy1.L antikoerper

Hintergrund:

Description: Pirh 2 (P53 induced RING-H2 protein), also known as RCHY1, it forms dimers through its N- and C-terminus in cells. The Pirh2 has ubiquitin-protein ligase activity and it binds with p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. The Pirh2 is oncogenic because loss of p53 function contributes directly to malignant tumor development. Pirh2 expression decreases the level of p53, and a decrease of endogenous Pirh2 expression increases p53 levels. Pirh2 is therefore considered, together with MDM2, to act as a negative regulator of p53 function.

Aliases: ARNIP, CHIMP, RNF199, RCHY1

Molekulargewicht: 30 kDa, 60 kDa (homodimer)

Gen-ID: 25898

HGNC: 25898