DKC1 Antikörper (AA 81-190) (Cy5.5)
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- Target Alle DKC1 Antikörper anzeigen
- DKC1 (Dyskeratosis Congenita 1, Dyskerin (DKC1))
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Bindungsspezifität
- AA 81-190
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser DKC1 Antikörper ist konjugiert mit Cy5.5
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Applikation
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Homologie
- Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Dyskerin
- Isotyp
- IgG
- Top Product
- Discover our top product DKC1 Primärantikörper
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- Applikationshinweise
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- DKC1 (Dyskeratosis Congenita 1, Dyskerin (DKC1))
- Andere Bezeichnung
- Dyskerin (DKC1 Produkte)
- Synonyme
- CBF5 antikoerper, DKC antikoerper, DKCX antikoerper, NAP57 antikoerper, NOLA4 antikoerper, XAP101 antikoerper, dyskerin antikoerper, fv62a07 antikoerper, wu:fa28f10 antikoerper, wu:fc87a02 antikoerper, wu:fi24a05 antikoerper, wu:fv62a07 antikoerper, zgc:110395 antikoerper, DKC1 antikoerper, cbf5 antikoerper, dkc antikoerper, nap57 antikoerper, nola4 antikoerper, xap101 antikoerper, BC068171 antikoerper, Nap57 antikoerper, AtCBF5 antikoerper, AtNAP57 antikoerper, homologue of NAP57 antikoerper, dyskerin pseudouridine synthase 1 antikoerper, microRNA 664b antikoerper, dyskeratosis congenita 1, dyskerin antikoerper, dyskeratosis congenita 1, dyskerin L homeolog antikoerper, homologue of NAP57 antikoerper, DKC1 antikoerper, MIR664B antikoerper, dkc1 antikoerper, dkc1.L antikoerper, Dkc1 antikoerper, NAP57 antikoerper
- Hintergrund
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Synonyms: CBF5, CBF5 homolog, Cbf5p homolog, DKC 1, DKC, Dkc1, DKC1_HUMAN, DKCX, Dyskeratosis congenita 1, Dyskeratosis congenita 1 dyskerin, Dyskerin, H/ACA ribonucleoprotein complex subunit 4, NAP 57, NAP57, NAP-57, NOLA 4, NOLA4, Nopp140 associated protein of 57 kDa, Nopp140-associated protein of 57 kDa, Nucleolar protein family A member 4, Nucleolar protein NAP57, snoRNP protein DKC1, XAP 101, XAP101.
Background: Dyskerin (NAP57) associates with the chaperone protein Nopp140 and forms a small ribonucleoprotein particle with GAR1 (NOLA1), NHP2 (NOLA2) and Nop10 for the isomerization of uridine to pseudouridine (1). GAR1, NHP2 and dyskerin localize to the dense fibrillar component of the nucleolus and in nuclear Cajal bodies (2). The dyskerin gene maps to chromosome Xq28 (3). Missense mutations in the dyskerin gene interfere with normal nuclear localization of dyskerin and cause Dyskeratosis congenita (DKC) (4). DKC is a rare, X-linked bone marrow disorder characterized by cutaneous hyperpigmentation, dystrophy of the nails, atrophy of the testicles and leukoplakia of the oral mucosa. The GAR1 gene maps to chromosome 4q25 (5,6). The NHP2 gene maps to chromosome 5q35.3 and encodes a 155-amino acid protein (2,7).
- Gen-ID
- 1736
- Pathways
- Telomere Maintenance
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