RAPGEF6 Antikörper (AA 601-700) (Biotin)

Produktnummer ABIN1700387

Produktdetails anti-RAPGEF6 Antikörper (Biotin)

Target: RAPGEF6 (Rap Guanine Nucleotide Exchange Factor (GEF) 6 (RAPGEF6))

Bindungsspezifität: AA 601-700

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAPGEF6 Antikörper ist konjugiert mit Biotin

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RAGEF2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu RAPGEF6

Target: RAPGEF6 (Rap Guanine Nucleotide Exchange Factor (GEF) 6 (RAPGEF6))

Andere Bezeichnung: RAGEF2 (RAPGEF6 Produkte)

Synonyme: KIA001LB antikoerper, PDZ-GEF2 antikoerper, PDZGEF2 antikoerper, RA-GEF-2 antikoerper, RAGEF2 antikoerper, A530068K01 antikoerper, AI844632 antikoerper, BB085664 antikoerper, C030018K18Rik antikoerper, Pdzgef2 antikoerper, Ragef2 antikoerper, mKIAA4052 antikoerper, wu:fa12b02 antikoerper, RAPGEF6 antikoerper, Rap guanine nucleotide exchange factor 6 antikoerper, Rap guanine nucleotide exchange factor (GEF) 6 antikoerper, RAPGEF6 antikoerper, Rapgef6 antikoerper, rapgef6 antikoerper

Hintergrund:

Synonyms: DKFZp667N084, DKFZp686I15116, KIA001LB, PDZ domain containing guanine nucleotide exchange factor GEF 2, PDZ domain containing guanine nucleotide exchange factor 2, PDZ domain containing guanine nucleotide exchange factor I, PDZ domain-containing guanine nucleotide exchange factor 2, PDZ GEF 2, PDZ GEF2, PDZ-GEF2, PDZGEF 2, PDZGEF2, RA GEF 2, RA GEF2, RA-GEF-2, RAGEF 2, Rap guanine nucleotide exchange factor GEF 6, Rap guanine nucleotide exchange factor 2, Rap guanine nucleotide exchange factor 6, RAPGEF6, RPGF6_HUMAN.

Background: RAPGEF6 is a guanine nucleotide exchange factor (GEF) that is expressed in a variety of tissues. Localizing to the cytoplasm and translocated to the plasma membrane upon ligand binding, RAPGEF6 contains an N-terminal Ras-GEF domain, a cyclic nucleotide monophosphate-binding domain, a PDZ (PSD-95/DlgA/ZO-1) domain, a Ras-associating (RA) domain and a Ras exchanger motif. RAPGEF6 is closely related to RAPGEF2 and both proteins exhibit GEF activity specific towards Rap 1 and Rap 2. In addition, RAPGEF6 is capable of binding to M-Ras via its RA domain. Due to alternative splicing events, two additional isoforms exist for RAPGEF6, namely PDZ-GEF2A and PDZ-GEF2B.