RAPGEF6 Antikörper (AA 601-700)

Produktnummer ABIN1713889

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch RAPGEF6 in IF (cc), IF (p), IHC (p) und IHC (fro). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für RAPGEF6 Antikörper (AA 601-700) (ABIN1713889)

Target: RAPGEF6 (Rap Guanine Nucleotide Exchange Factor (GEF) 6 (RAPGEF6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAPGEF6 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-RAPGEF6 Antikörper

Bindungsspezifität: AA 601-700

Verwendungszweck: RAGEF2 Polyclonal Antibody

Homologie: Human,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RAGEF2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu RAPGEF6

Target: RAPGEF6 (Rap Guanine Nucleotide Exchange Factor (GEF) 6 (RAPGEF6))

Andere Bezeichnung: RAGEF2

Hintergrund:

Synonyms: DKFZp667N084, DKFZp686I15116, KIA001LB, PDZ domain containing guanine nucleotide exchange factor GEF 2, PDZ domain containing guanine nucleotide exchange factor 2, PDZ domain containing guanine nucleotide exchange factor I, PDZ domain-containing guanine nucleotide exchange factor 2, PDZ GEF 2, PDZ GEF2, PDZ-GEF2, PDZGEF 2, PDZGEF2, RA GEF 2, RA GEF2, RA-GEF-2, RAGEF 2, Rap guanine nucleotide exchange factor GEF 6, Rap guanine nucleotide exchange factor 2, Rap guanine nucleotide exchange factor 6, RAPGEF6, RPGF6_HUMAN.

Background: RAPGEF6 is a guanine nucleotide exchange factor (GEF) that is expressed in a variety of tissues. Localizing to the cytoplasm and translocated to the plasma membrane upon ligand binding, RAPGEF6 contains an N-terminal Ras-GEF domain, a cyclic nucleotide monophosphate-binding domain, a PDZ (PSD-95/DlgA/ZO-1) domain, a Ras-associating (RA) domain and a Ras exchanger motif. RAPGEF6 is closely related to RAPGEF2 and both proteins exhibit GEF activity specific towards Rap 1 and Rap 2. In addition, RAPGEF6 is capable of binding to M-Ras via its RA domain. Due to alternative splicing events, two additional isoforms exist for RAPGEF6, namely PDZ-GEF2A and PDZ-GEF2B.