ERCC8 Antikörper (AA 161-260) (Alexa Fluor 488)

Produktnummer ABIN1694824

Produktdetails anti-ERCC8 Antikörper (Alexa Fluor 488)

Target: ERCC8 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8))

Bindungsspezifität: AA 161-260

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ERCC8 Antikörper ist konjugiert mit Alexa Fluor 488

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ERCC8/CSA

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu ERCC8

Target: ERCC8 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8))

Andere Bezeichnung: ERCC8/CSA (ERCC8 Produkte)

Synonyme: zgc:103550 antikoerper, CKN1 antikoerper, CSA antikoerper, UVSS2 antikoerper, Ckn1 antikoerper, 2410022P04Rik antikoerper, 2810431L23Rik antikoerper, 4631412O06Rik antikoerper, B130065P18Rik antikoerper, Csa antikoerper, excision repair cross-complementation group 8 antikoerper, ERCC excision repair 8, CSA ubiquitin ligase complex subunit antikoerper, excision repaiross-complementing rodent repair deficiency, complementation group 8 antikoerper, ercc8 antikoerper, ERCC8 antikoerper, Ercc8 antikoerper

Hintergrund:

Synonyms: CSA, CKN1, UVSS2, DNA excision repair protein ERCC-8, Cockayne syndrome WD repeat protein CSA, ERCC8

Background: Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner, ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes.

Gen-ID: 1161

UniProt: Q13216

Pathways: DNA Reparatur, Positive Regulation of Response to DNA Damage Stimulus