Dnmt2 Antikörper (AA 61-160) (Alexa Fluor 350)
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- Target Alle Dnmt2 (TRDMT1) Antikörper anzeigen
- Dnmt2 (TRDMT1) (tRNA Aspartic Acid Methyltransferase 1 (TRDMT1))
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Bindungsspezifität
- AA 61-160
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Dnmt2 Antikörper ist konjugiert mit Alexa Fluor 350
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Applikation
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Homologie
- Human,Mouse,Rat,Cow,Sheep,Pig
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Dnmt2
- Isotyp
- IgG
- Top Product
- Discover our top product TRDMT1 Primärantikörper
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- Applikationshinweise
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- Dnmt2 (TRDMT1) (tRNA Aspartic Acid Methyltransferase 1 (TRDMT1))
- Andere Bezeichnung
- Dnmt2 (TRDMT1 Produkte)
- Synonyme
- MGC89267 antikoerper, DMNT2 antikoerper, DNMT2 antikoerper, MHSAIIP antikoerper, PUMET antikoerper, RNMT1 antikoerper, Dnmt2 antikoerper, Rnmt2 antikoerper, dnmt2 antikoerper, tRNA aspartic acid methyltransferase 1 antikoerper, tRNA aspartic acid methyltransferase 1 L homeolog antikoerper, trdmt1 antikoerper, TRDMT1 antikoerper, Trdmt1 antikoerper, trdmt1.L antikoerper
- Hintergrund
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Synonyms: dDNMT, D mMT 2, D mMT2, DNA cytosine 5 methyltransferase 2, DNA cytosine 5 methyltransferase like protein 2, DNA cytosine-5-methyltransferase-like protein 2, DNA 5 cytosine methyltransferase, DNA methyltransferase 2, DNA methyltransferase homolog HsaIIP, DNA MTase homolog HsaIIP, Dnmt 2, Dnmt2, M.HsaIIP, MHsaIIP, nmt 2, nmt2, OTTHUMP00000045198, PuMet, RNMT 1, RNMT1, TRDMT 1, TRDMT_HUMAN, TRDMT1, tRNA cytosine 5 methyltransferase, tRNA cytosine38-C5-methyltransferase, tRNA aspartic acid methyltransferase 1, tRNA aspartic acid methyltransferase 1 variant 1, tRNA aspartic acid methyltransferase 1 variant 2, tRNA aspartic acid methyltransferase 1 variant 3, tRNA aspartic acid methyltransferase 1 variant 4, tRNA aspartic acid methyltransferase 1 variant 5, tRNA aspartic acid methyltransferase 1 variant 8.
Background: Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines residing in the dinucleotide CpG motif, and this methylation results in transcriptional repression of the target gene. The Dnmt enzymes are encoded by independent genes. Dnmt1 is the most abundant, and it preferentially methylates hemimethylated DNA and coordinates gene expression during development. Additional mammalian Dnmt proteins include Dnmt2 and Dnmt3. Dnmt2 lacks the large N-terminal regulator domain of Dnmt1, is expressed at substantially lower levels in adult tissues, and is likely involved in methylating newly integrated retroviral DNA. Dnmt3a and Dnmt3b are encoded by two distinct genes, but both are abundantly expressed in embryonic stem cells, where they also methylate CpG motifs on DNA.
- Gen-ID
- 1787
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